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A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications
ArticleAbstract: Streptomyces clavuligerus is a Gram-positive bacterium that is a high producer of secondary metaboliPalabras claves:Antimicrobial peptide, Horizontal gene transfer, Hymenoptera, pSCL4, Streptomyces clavuligerus ATCC 27064Autores:Daniela Santander-Gordón, Eduardo Tejera, Sebastián Ayala-Ruano, Vinicio Danilo Armijos-Jaramillo, Yunierkis Perez-CastilloFuentes:googlescopusComputational chemistry comparison of stable/nonstable protein mutants classification models based on 3d and topological indices
ArticleAbstract: In principle, there are different protein structural parameters that can be used in computational chPalabras claves:Protein stability, Protein structure, Spectral moments, topological indicesAutores:González‐díaz H., Podda G., Uriarte E., Yunierkis Perez-CastilloFuentes:googlescopusAntileishmanial Activity of Cinnamic Acid Derivatives against Leishmania infantum
ArticleAbstract: Leishmania infantum is the etiological agent of visceral leishmaniasis (VL) in South America, the MePalabras claves:antiparasitic activity, cinnamamide, cinnamate, Medicinal Plant, Natural productAutores:Almeida F.S., de Morais M.C., Keesen T.d.S.L., Medeiros G.A., Rocha J.d.C., Sousa D.P.D., Yunierkis Perez-CastilloFuentes:googlescopusArticle bioactive terpenes and their derivatives as potential SARS-CoV-2 proteases inhibitors from molecular modeling studies
ArticleAbstract: The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel coronavirus; the Severe AcutePalabras claves:covid-19, MERS-CoV, Middle East Respiratory Syndrome Virus, Natural products, plants, saponins, SARS-CoV, SARS-COV-2, Terpenoid, virusesAutores:Bezerra Filho C.d.S.M., Diniz L.R.L., Elshabrawy H.A., Sousa D.P.D., Yunierkis Perez-CastilloFuentes:googlescopusCytotoxic and antifungal amides derived from ferulic acid: Molecular docking and mechanism of action
ArticleAbstract: Amides derived from ferulic acid have a wide spectrum of pharmacological activities, including antitPalabras claves:Autores:Bezerra D.P., De Castro R.D., de Morais M.C., de Souza Santos L., Silva V.R., Soares M.B.P., Sousa D.P.D., Yunierkis Perez-CastilloFuentes:googlescopusFrom a coenzyme-like mechanism to homochirality
ArticleAbstract: Inspired in a coenzyme-like behavior, an alternative mechanism to induce homochirality within a smalPalabras claves:Autocatalysis, Co-enzymatic reactions, Homochirality, Stochastic modelingAutores:José Suárez-Lezcano, Leyva Y., Martin O., Yovani Marrero-Ponce, Yunierkis Perez-CastilloFuentes:scopusFrom flamingo dance to (desirable) drug discovery: a nature-inspired approach
ReviewAbstract: The therapeutic effects of drugs are well known to result from their interaction with multiple intraPalabras claves:Autores:Aminael Sánchez-Rodríguez, Borges F., Eduardo Tejera, Mangiatordi G.F., Maykel Cruz-Monteagudo, Medina-Franco J.L., Natalia Dias Soeiro Cordeiro M., Nicolotti O., Schürer S.C., Yunierkis Perez-CastilloFuentes:googlescopusHP-Lattice QSAR for dynein proteins: Experimental proteomics (2D-electrophoresis, mass spectrometry) and theoretic study of a Leishmania infantum sequence
ArticleAbstract: The toxicity and inefficacy of actual organic drugs against Leishmaniosis justify research projectsPalabras claves:2D-electrophoresis, BLAST, complex networks, Dyneins, HP-Lattice model, Leishmania infantum, Mass spectrometry, Parasites proteomics, QSAR, Sequence alignment, Spectral momentsAutores:Bolas-Fernández F., Chou K.C., Dea-Ayuela M.A., González‐díaz H., Meneses-Marcel A., Ubeira F.M., Yunierkis Perez-CastilloFuentes:googlescopusSynthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study
ArticleAbstract: The severity of infectious diseases associated with the resistance of microorganisms to drugs highliPalabras claves:amides, Antimicrobial, Candida, cinnamic acid, esters, mechanism of action, Medicinal Plant, Molecular docking, Natural product, S. AureusAutores:de Morais M.C., de Oliveira Lima E., Sousa D.P.D., Yunierkis Perez-CastilloFuentes:googlescopusTI2BioP: Topological Indices to BioPolymers. Its practical use to unravel cryptic bacteriocin-like domains
ArticleAbstract: Bacteriocins are proteinaceous toxins produced and exported by both gram-negative and gram-positivePalabras claves:Alignment methods, Artificial secondary structure, Bacteriocin, Spectral moments, topological indicesAutores:Agüero-Chapin G., Antunes A., Molina-Ruiz R., Morales-Helguera A., Pérez-Machado G., Vasconcelos V., Yunierkis Perez-CastilloFuentes:googlescopus