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A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project
ArticleAbstract: Background: The characterization of the first episode of psychosis and how it should be treated arePalabras claves:Antipsychotic, first episode psychosis, pharmacovigilance, polytherapy, psychotropic drugs, SchizophreniaAutores:Adrián LLerena, Aguilar E.J., Albacete A., Alonso-Solís A., Amoretti S., Baeza I., Balanzá-Martínez V., Bernardo M., Bioque M., Bobes J., Bulbena A., Butjosa A., Cabrera B., Castro-Fornieles J., Contreras F., Corripio I., Cuesta M.J., Díaz-Caneja M.C., Escartí M.J., García Bernardo E., García-Portilla M.P., Gassó P., González I., González-Pinto A., Grasa E., Hernandez M., Ibáñez Á., Lafuente A., Landín-Romero R., Lobo A., Mané A., Mas S., Mezquida G., Modrego F., Morales-Muñoz I., Parellada M., Rodriguez-Jimenez R., Ruiz P., Saiz-Ruiz J., Sánchez-Torres A.M., Sarró S., Segarra R., Tapia-Casellas C., Torrent C., Vieta E., Zabala Rabadán A.Fuentes:scopusA combined high CYP2D6-CYP2C19 metabolic capacity is associated with the severity of suicide attempt as measured by objective circumstances
ArticleAbstract: This study examined, for the first time, whether a high CYP2D6-CYP2C19 metabolic capacity combinatioPalabras claves:Autores:Adrián LLerena, Blasco-Fontecilla H., Courtet P., Delgado A., Guillaume S., Jaussent I., Naranjo M.E.G., Penãs-Lledó E.M.Fuentes:scopusA one-year follow-up study of treatment-compliant suicide attempt survivors: relationship of CYP2D6-CYP2C19 and polypharmacy with suicide reattempts
ArticleAbstract: This study of a cohort of 1-year treatment-compliant survivors of a suicide attempt examined for thePalabras claves:Autores:Adrián LLerena, Cortés-Martínez A., Courtet P., de Andrés F., Dubois J., Guillaume S., Kahn J.P., Leboyer M., Olié E., Penãs-Lledó E.M.Fuentes:scopusABCB1 gene polymorphisms and violent suicide attempt among survivors
ArticleAbstract: Introduction: Those suicide attempters that choose violent methods dramatically diminish the possibiPalabras claves:ABCB1, Suicide attempt, Violent suicide methodsAutores:Adrián LLerena, Courtet P., Delgado A., Guillaume S., Jaussent I., Naranjo M.E.G., Penãs-Lledó E.M.Fuentes:scopusClinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update
ReviewAbstract: Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokiPalabras claves:Autores:Adrián LLerena, Callaghan J.T., Caudle K.E., Fohner A.E., Formea C.M., Gaedigk A., Huddart R., Karnes J.H., Klein T.E., Mintzer S., Phillips E.J., Rettie A.E., Somogyi A.A., Ta Michael Lee M., Whirl-Carrillo M.Fuentes:scopusClinical implementation of pharmacogenetics and personalized drug prescription based on e-health: The MedeA initiative
ArticleAbstract:Palabras claves:Autores:Adrián LLerena, Cobaleda J., de Andrés F., Mata-Martín C., Penãs-Lledó E.M., Pijierro A., Sánchez C.L.Fuentes:scopusClinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs
ReviewAbstract: CYP2D6 is described as the most relevant enzyme in the metabolism of many antipsychotic drugs. Its cPalabras claves:Antipsychotic drugs, CYP2D6, pharmacogenetics, PharmacogenomicsAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P., Penãs-Lledó E.M.Fuentes:scopusClinical use of pre-emptive pharmacogenetic programmes
OtherAbstract:Palabras claves:Autores:Adrián LLerena, Penãs-Lledó E.M.Fuentes:scopusClozapine withdrawal symptoms after change to sertindole in a schizophrenic patient
ArticleAbstract: A 30-year-old male patient with paranoid schizophrenia was on clozapine therapy for more than five yPalabras claves:Autores:Adrián LLerena, Berecz R., De la Rubia A., Degrell I., Glaub T., Kellermann M.Fuentes:scopusAssessing clinical and functional outcomes in a gene-environment interaction study in first episode of psychosis (PEPs)
ArticleAbstract: The PEPs study is a multicenter, naturalistic, prospective, longitudinal study designed to evaluatePalabras claves:First episode of psychosis, Functional assessment, outcome measures, Psychopathology assessment, SchizophreniaAutores:Adrián LLerena, Arango C., Bernardo M., Bioque M., Cabrera B., Castro-Fornieles J., Cuesta M.J., Parellada M., Saiz-Ruiz J., Sanjuán J.Fuentes:scopus