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Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: Pharmacogenetic implications
ArticleAbstract: CYP2D6 codes for a protein that is vastly involved in the metabolism of various substances. This genPalabras claves:CYP2D6, CYP450, Metabolic profile, pharmacogenetics, Pharmacogenomics, polymorphism, Portuguese populationAutores:Adrián LLerena, Albuquerque J., Grazina M., Naranjo M.E.G., Ribeiro C.Fuentes:scopusClinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs
ReviewAbstract: CYP2D6 is described as the most relevant enzyme in the metabolism of many antipsychotic drugs. Its cPalabras claves:Antipsychotic drugs, CYP2D6, pharmacogenetics, PharmacogenomicsAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P., Penãs-Lledó E.M.Fuentes:scopus4th ESPT Conference: Pharmacogenomics and personalized medicine - Research progress and clinical implementation
ArticleAbstract: The Fourth European Society of Pharmacogenomics and Personalized Therapy biennial conference was orgPalabras claves:clinical implementation, ESPT conference, personalized medicine, PharmacogenomicsAutores:Adrián LLerena, Ansari M., Cascorbi I., Drago F., Gozzo L., Ingelman-Sundberg M., Katsila T., Manolopoulos V.G., Marc J., Marchetti P., Meyer U.A., Mlakar V., Nofziger C., Paulmichl M., Pearson E., Re M.D., Simmaco M., Sipeky C., Stanković S., Suarez-Kurtz G., Van Schaik R.H.N.Fuentes:scopusCurrent insights into interethnic variability in testicular cancers: Population pharmacogenetics, clinical trials, genetic basis of chemotherapyinduced toxicities and molecular signal transduction
ReviewAbstract: Testicular cancer is an aggressive malignancy with a rising incidence rate across the globe. TesticuPalabras claves:clinical trials, ethnicity, Molecular aspects, pharmacogenetics, Pharmacogenomics, population pharmacogenetics, Precision Medicine, signal transduction, Testicular cancer, Testicular seminoma, Toxicity, Variant polymorphismAutores:Adrián LLerena, de Andrés F., Kothari R., Mishra A., Nair S., Vasistha A.Fuentes:scopusCYP2D6 polymorphism: Implications for antipsychotic drug response, schizophrenia and personality traits
ReviewAbstract: The CYP2D6 gene is highly polymorphic, causing absent (poor metabolizers), decreased, normal or incrPalabras claves:Adverse side effects, antipsychotics, CYP2D6, personality, pharmacogenetics, Pharmacogenomics, QTc, Schizophrenia, vulnerabilityAutores:Adrián LLerena, Dorado P., Penãs-Lledó E.M.Fuentes:scopusPharmacogenetic research activity in Central America and the Caribbean: A systematic review
ReviewAbstract: Aim: The present review was aimed at analyzing the pharmacogenetic scientific activity in Central AmPalabras claves:Biomarkers, Caribbean Region, Central America, pharmacogenetics, PharmacogenomicsAutores:Adrián LLerena, Campos M.D.L.A., Céspedes-Garro C., Duconge J., Humberto Fariñas, Montané-Jaime L.K., Naranjo M.E.G., Penãs-Lledó E.M., Ramirez R., Roblejo H., Rodrigues-Soares F., Serrano V., Villagrán C.I.Fuentes:scopusPharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity
ReviewAbstract: Debrisoquine hydroxylation polymorphism is by far the most thoroughly studied genetic polymorphism oPalabras claves:CYP2D6, Cytochrome p450, debrisoquine, PharmacogenomicsAutores:Adrián LLerena, Dorado P., Penãs-Lledó E.M.Fuentes:scopusPharmacogenomics and personalized medicine in clinical practice
Conference ObjectAbstract: The Santorini Conference on prospective biology, genomics and pharmacogenomics occurs every 2 years.Palabras claves:Biomarkers, cytochromes, personalized medicine, pharmacogenetics, Pharmacogenomics, theranosticsAutores:Adrián LLerena, Dechairo B., Huriez A., J Yeo K., KüÃhn A., Manolopoulos V.G., Ragia G., Siest G., Van Schaik R.H.N.Fuentes:scopusPharmacogenomics education in medical and pharmacy schools: Conclusions of a global survey
ArticleAbstract: Aim: The need for pharmacogenomic education is becoming more and more urgent. Our aim was to evaluatPalabras claves:Education, global survey, Medicine, Pharmacogenomics, Pharmacy, recommendationsAutores:Adrián LLerena, Ansari M., Brandslund I., Cascorbi I., Dedoussis G., DI Resta C., Flordellis C.S., Fuhr U., Gurwitz D., Karas Kuželički N., Lunshof J.E., Manolopoulos V.G., Marc J., Pazzagli M., Prodan Žitnik I., Schwab M., Siest S., Simmaco M., Stingl J.C., Van Schaik R.H.N., Vermeersch P.Fuentes:scopusWhat is the future of pharmacogenomics in pain management?
OtherAbstract:Palabras claves:Chronic pain, clinical translation, Guidelines, PharmacogenomicsAutores:Adrián LLerena, Margarit C., Peiró A.M.Fuentes:scopus