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Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: Application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship
ArticleAbstract: The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several cPalabras claves:CYP2D6, debrisoquine, HPLC, Metabolic ratioAutores:Adrián LLerena, Berecz R., Cáceres M.C., Cobaleda J., Dorado P., González I.Fuentes:scopusDebrisoquine oxidation in schizophrenic patients treated with neuroleptics
ArticleAbstract:Palabras claves:debrisoquine, Neuroleptics, OXIDATION, SchizophreniaAutores:Adrián LLerena, Benitez Rodriguez J., Buemi A.L., Caputi A.P., Cobaleda J., García M.A., Piña B., Spina E.Fuentes:scopusCYP2D6-1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers
ArticleAbstract: Background & aim: The CYP2D6-1584C>G polymorphism (rs1080985) has been identified as a major factorPalabras claves:1584C>G, CYP2D6, debrisoquine, Healthy volunteers, ultrarapid metabolismAutores:Adrián LLerena, Alvárez M., Calzadilla L.R., Dorado P., González I., Naranjo M.E.G., Penãs-Lledó E.M., Pérez B., Ramirez R.Fuentes:scopusEffect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes
ArticleAbstract: Sixteen hospitalized white European Spanish psychiatric patients treated with thioridazine alone werPalabras claves:CYP2D6, debrisoquine, Inhibition, ThioridazineAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P., Fernández-Salguero P.Fuentes:scopusHaloperidol disposition is dependent on debrisoquine hydroxylation phenotype
ArticleAbstract: To investigate the importance of genetic factors for the regulation of haloperidol metabolism, we stPalabras claves:debrisoquine, Haloperidol, humans, pharmacogeneticsAutores:Adrián LLerena, Alm C., Bertilsson L., Dahl M.L., Ekqvist B.Fuentes:scopusHaloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: Increased plasma levels of the reduced metabolite in poor metabolizers
ArticleAbstract: We have previously shown that the disposition of haloperidol is decreased in poor (PM) compared to ePalabras claves:debrisoquine, humans, pharmacogenetics, Reduced haloperidolAutores:Adrián LLerena, Bertilsson L., Dahl M.L., Ekqvist B.Fuentes:scopusInterethnic differences in drug metabolism: Influence of genetic and environmental factors on debrisoquine hydroxylation phenotype
Conference ObjectAbstract: Genetic and environmental factors are determinants of the interindividual and interethnic variabilitPalabras claves:CYP2D6, debrisoquine, gender, pharmacogenetics, smokingAutores:Adrián LLerena, Benitez Rodriguez J., Cobaleda J., Martínez C.Fuentes:scopusPharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity
ReviewAbstract: Debrisoquine hydroxylation polymorphism is by far the most thoroughly studied genetic polymorphism oPalabras claves:CYP2D6, Cytochrome p450, debrisoquine, PharmacogenomicsAutores:Adrián LLerena, Dorado P., Penãs-Lledó E.M.Fuentes:scopusQTc interval lengthening and debrisoquine metabolic ratio in psychiatric patients treated with oral haloperidol monotherapy
OtherAbstract:Palabras claves:debrisoquine, Haloperidol, QTcAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P.Fuentes:scopusQTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients
ArticleAbstract: Thioridazine cardiotoxicity has been associated with a prolonged heart-rate corrected QT (QTc) interPalabras claves:CYP2D6, debrisoquine, QTc lengthening, ThioridazineAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P.Fuentes:scopus