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OMICS A Journal of Integrative Biology(3)
Pharmacogenomics(3)
Drug Metabolism and Drug Interactions(2)
Clinical Pharmacology and Therapeutics(1)
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Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans
ArticleAbstract: We present the distribution of CYP2D6, CYP2C9, and CYP2C19 variants and predicted phenotypes in 33 nPalabras claves:Autores:Adrián LLerena, Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Ferreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Gilman R.H., Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Michelin L.A., Monroy-Jaramillo N., Moya G.E., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Santiago Terán, Sarmiento A.P., Scliar M.O., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Zamudio R.Fuentes:googlescopusEditorial
OtherAbstract:Palabras claves:Autores:Administrador Revistas UTE, Adrián LLerena, Aguilar Gordón F.D.R., Alejandro Speck-Planche, Alfred Kron̈er, Alvaro Santiago Solano Gallegos, Ayestarán S., Benson A., Darío R. Páez, Darwin Ordoñez Iturralde, Davey K., David Ricardo Achig Balarezo, Davila A., Eduardo V. Ludeña, Elisa Bonaccorso, Eugenia Wickens, Eve Cerón Pérez, Floralba del Rocío Aguilar-Gordón, Freddy Portilla Farfán, Gisela Raymond Cornejo, Gustavo Moreno-Martín, Henry Pazmiño A, Hoorn C., Hugo Mauricio Ortega Andrade, Iankova K., Jaime Padilla Verdugo, Jaime Patricio Abad Vázquez, Javier González Díez, Jefferson Moreno Guaicha, Jimena Peñaherrera Wilches, José Luis Crespo-Fajardo, Juan Manuel Guayasamin, Klerkx J., Licinio J., Linder H., Marcos De Donato, María Sol Villagómes, Marian Wiercigroch, Matilde J. Flores Urbáez, Miriam Gallegos, Naranjo-Gil D., Nelson José Labarca Ferrer, Nicola Pontarollo, Nikola Petrovic, Orville-Thomas W.J., Palavitsinis N., Pedro Jimenez-Pacheco, Pedro Longart, Rafael Iturralde Solórzano, Richard J. Aspinall, Schandelmeier H., Smeyers Y.G., Stern R.J., Tilbury J., Viazzo P.P., Xavier Ochoa, Yachana , Yachana Revista Científica, Yntze van der Hoek, Zulbey Rivero de RodríguezFuentes:googlerraaescopusChallenges and Opportunities for Clinical Pharmacogenetic Research Studies in Resource-limited Settings: Conclusions From the Council for International Organizations of Medical Sciences–Ibero-American Network of Pharmacogenetics and Pharmacogenomics Meeting
ArticleAbstract: Purpose: The symposium Health and Medicines in Indigenous Populations of America was organized by thPalabras claves:CIOMS-RIBEF, clinical research, pharmacogenetics, resource-limited settingsAutores:Adrián LLerena, Diwakar S., Enrique Terán, Galaviz-Hernandez C., Gil J.P., Isabel Hernández, Lara-Riegos J., Molina-Guarneros J.A., Moya G.E., Nair S., Penãs-Lledó E.M., Rägo L., Ramírez-Roa R., Sosa-Macías M.G., Tarazona-Santos E.M., Verde I.Fuentes:googlescopusInterethnic differences in UGT1A4 genetic polymorphisms between Mexican Mestizo and Spanish populations
ArticleAbstract: UDP-glucuronosyltransferase 1A4 (UGT1A4) is a phase II drug-metabolizing enzyme that catalyzes the gPalabras claves:Glucuronidation, Interethnic differences, Mexican-Mestizo, Spaniards, UGT1A4Autores:Adrián LLerena, Alonso M.E., Cobaleda J., Dorado P., Gallego-Aguilera A., López M.L., MELANIE BRIGETTE ARROYO LOPEZ, Monroy-Jaramillo N., Ortega A., Penãs-Lledó E.M., Silva-Zolezzi I.Fuentes:googlescopusInterethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 ibero-and native Americans: RIBEF-CEIBA consortium report on population pharmacogenomics
ArticleAbstract: Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of gPalabras claves:Amerindians, CYP2C19, CYP2C9, CYP2D6, drug metabolism, LATIN AMERICANS, pharmacogenetics, Precision MedicineAutores:Adrián LLerena, Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Fcrreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Gilman R.H., Gouveia M.H., Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Monroy-Jaramillo N., Moya G.E., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Santiago Terán, Sarmiento A.P., Scliar M.O., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Zamudio R.Fuentes:googlescopusPharmacogenetic potential biomarkers for carbamazepine adverse drug reactions and clinical response
ReviewAbstract: Carbamazepine (CBZ) is a first-line widely used anticonvulsant. It has a narrow therapeutic index anPalabras claves:adverse drug reaction, carbamazepine, Drug resistance, genetic polymorphism, human leukocyte antigen (HLA), pharmacogeneticsAutores:Adrián LLerena, Cook H.J., Galindo I.F., López M.L., MELANIE BRIGETTE ARROYO LOPEZ, Monroy-Jaramillo N., Vázquez A.O.Fuentes:googlescopusPharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America
Conference ObjectAbstract: Congress of Pharmacogenetics and Personalized Medicine. Ethnicity, clinical implementation and regulPalabras claves:clinical trials, Latin American populations, metabolic genotypes, Metabolic phenotypes, native populations, pharmacogenetics, pharmacovigilanceAutores:Adrián LLerena, Altamirano C., Céspedes-Garro C., Enrique Terán, Francisco J.López Hernández, Galaviz-Hernandez C., Humberto Fariñas, Jung-Cook H., López-López M., MARTHA FORS, Martha M. Fors-López, Moya G.E., Ramirez R., Remírez D., Sosa-Macías M.G., Tarazona-Santos E.M., William F. WatersFuentes:googlescopusPharmacogenetics of the antiepileptic drugs phenytoin and lamotrigine
ReviewAbstract: Patients treated with antiepileptic drugs can exhibit large interindividual variability in clinicalPalabras claves:antiepileptic drug, Cytochrome p450, lamotrigine, pharmacogenetics, Phenytoin, UDP-glucuronosyltransferase (UGT)Autores:Adrián LLerena, Dorado P., ElisaAlonso M., Jung-Cook H., López M.L., Machín E., MELANIE BRIGETTE ARROYO LOPEZ, Monroy-Jaramillo N., Penãs-Lledó E.M.Fuentes:googlescopusPopulation pharmacogenetics of Ibero-Latinoamerican populations (MESTIFAR 2014)
Conference ObjectAbstract: MESTIFAR 2014 28-30 November 2014, Panama City, Panama The CEIBA consortium was created within the IPalabras claves:Cytochrome p450, drug metabolism, genome-wide analyses, Ibero-Americans populations, Metabolic phenotypes, next-generation sequencing, pharmacogenetics, Population geneticsAutores:Acosta H., Adrián LLerena, Céspedes-Garro C., Enrique Terán, Galaviz-Hernandez C., Moya G.E., Penãs-Lledó E.M., Ramirez R., Sosa-Macías M.G., Tarazona-Santos E.M.Fuentes:googlescopusMultiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach
ArticleAbstract: Phenotyping of the CYP450 enzyme activities contributes to personalized medicine, but the past phenoPalabras claves:Autores:Adrián LLerena, Bovera M., de Andrés F., Enrique Terán, Humberto Fariñas, Santiago TeránFuentes:googlescopus