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The EPIDAT program: Uses and perspectives
OtherAbstract:Palabras claves:Autores:Bacallao J., Barbeito G.N., Humberto Fariñas, Mujica O.J., Santiago M.I., Silva-Aycaguer L.C., Vázquez E., Vidal X.H.Fuentes:scopusPharmacogenetics: ethnicity, treatment and health in Latin American populations
Abstract: The Ibero-American Network of Pharmacogenetics and Pharmacogenomics (RIBEF) studies Latin American pPalabras claves:Biomarkers, ethnicity, Latin American, Native Americans, pharmacogeneticsAutores:Adrián LLerena, Enrique Terán, Eugenia Dolores Ruiz-Cruz, Fricke-Galindo I., Galaviz-Hernandez C., Garcia-Ortiz J.E., Humberto Fariñas, Isabel Hernández, Lara-Riegos J., López-López M., Lucero Monterde, Molina-Guarneros J.A., Moya G.E., Penãs-Lledó E.M., Ramírez-Roa R., Rodrigues-Soares F., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A.Fuentes:scopusWorldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes
ReviewAbstract: Introduction: Notably differences in CYP2C9 allele frequencies among worldwide populations have beenPalabras claves:CYP2C9, ethnicity, Genotype, PhenotypeAutores:Adrián LLerena, Céspedes-Garro C., de Andrés F., Fricke-Galindo I., Humberto Fariñas, López-López M., Naranjo M.E.G., Penãs-Lledó E.M., Rodrigues-Soares F.Fuentes:scopusGenomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans
ArticleAbstract: We present the distribution of CYP2D6, CYP2C9, and CYP2C19 variants and predicted phenotypes in 33 nPalabras claves:Autores:Adrián LLerena, Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Ferreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Gilman R.H., Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Michelin L.A., Monroy-Jaramillo N., Moya G.E., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., René D.H., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Roxana Zamudio, Santiago Terán, Sarmiento A.P., Scliar M.O., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Zamudio R.Fuentes:googlescopusInterethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 ibero-and native Americans: RIBEF-CEIBA consortium report on population pharmacogenomics
ArticleAbstract: Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of gPalabras claves:Amerindians, CYP2C19, CYP2C9, CYP2D6, drug metabolism, LATIN AMERICANS, pharmacogenetics, Precision MedicineAutores:Adrián LLerena, Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Fcrreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Gilman R.H., Gouveia M.H., Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Monroy-Jaramillo N., Moya G.E., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., René D.H., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Roxana Zamudio, Santiago Terán, Sarmiento A.P., Scliar M.O., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Zamudio R.Fuentes:googlescopusInterethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations
ReviewAbstract: Introduction: The frequency of CYP2D6 alleles, related to either a lack of or increased enzymatic acPalabras claves:CYP2D6, CYP2D6∗10, CYP2D6∗17, CYP2D6∗29, CYP2D6∗4, CYP2D6∗41, ethnicity, Poor metabolizers, population pharmacogenetics, Ultrarapid metabolizersAutores:Adrián LLerena, Humberto Fariñas, Naranjo M.E.G., Penãs-Lledó E.M., Rodrigues-Soares F., Tarazona-Santos E.M.Fuentes:scopusMDR-1 genotypes and quetiapine pharmacokinetics in healthy volunteers
ArticleAbstract: Background: P-glycoprotein is an efflux transporter encoded by the multidrug-resistance MDR-1 gene,Palabras claves:MDR-1, P-Glycoprotein, Pharmacokinetic, QuetiapineAutores:Adrián LLerena, Dorado P., Estévez-Carrizo F.E., González-Vacarezza N., Humberto Fariñas, Penãs-Lledó E.M.Fuentes:scopusRelevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population
ArticleAbstract: CYP2C9, CYP2C19 and CYP2D6 metabolize around 40 % of drugs and their genes vary across populations.Palabras claves:Afro-Caribbean, Amerindian, COSTA RICA, CYP2C19, CYP2C9, CYP2D6, Genomic ancestryAutores:Adrián LLerena, Alonso-Vilatela E., Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Ferreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Graciela E. Moya, Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Monroy-Jaramillo N., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., René D.H., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Santiago Terán, Sarmiento A.P., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Vázquez T.C.Fuentes:scopusMultiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach
ArticleAbstract: Phenotyping of the CYP450 enzyme activities contributes to personalized medicine, but the past phenoPalabras claves:Autores:Adrián LLerena, Bovera M., de Andrés F., Enrique Terán, Humberto Fariñas, Santiago TeránFuentes:googlescopusPharmacogenetic research activity in Central America and the Caribbean: A systematic review
ReviewAbstract: Aim: The present review was aimed at analyzing the pharmacogenetic scientific activity in Central AmPalabras claves:Biomarkers, Caribbean Region, Central America, pharmacogenetics, PharmacogenomicsAutores:Adrián LLerena, Campos M.D.L.A., Céspedes-Garro C., Duconge J., Humberto Fariñas, Montané-Jaime L.K., Naranjo M.E.G., Penãs-Lledó E.M., Ramirez R., Roblejo H., Rodrigues-Soares F., Serrano V., Villagrán C.I.Fuentes:scopus