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Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus
OtherAbstract: The mechanism of action of conventional antidepressants (e.g. imipramine) has been linked to modulatPalabras claves:Autores:Harrison CastroFuentes:googleAsthma exacerbations and inhaled corticosteroids
OtherAbstract: Sir—TW Harrison and colleagues (Jan 24, p 271) 1 examine the effects of doubling the dose of inhaledPalabras claves:Autores:Harrison CastroFuentes:googleAzithromycin for acute exacerbations of asthma: the AZALEA randomized clinical trial
OtherAbstract: Importance Guidelines recommend against antibiotic use to treat asthma attacks. A study with telithrPalabras claves:Autores:Harrison CastroFuentes:googleA comparative assessment of γ-secretase activity in transgenic and non-transgenic rodent brain
OtherAbstract: Amyloid-beta (Aβ) deposits are one of the hallmarks of the neuropathological degeneration observed iPalabras claves:Autores:Harrison CastroFuentes:googleCatalytic site-directed γ-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and β-APP cleavages
OtherAbstract: The generation of γ-secretase inhibitors which block the release of β-amyloid peptide (Aβ) has longPalabras claves:Autores:Harrison CastroFuentes:googleApoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling
OtherAbstract: In this report, inhibitors of the γ-secretase enzyme have been exploited to characterize the antiproPalabras claves:Autores:Harrison CastroFuentes:googleAlkenyl-substituted spirocyclic sulfamides as inhibitors of gamma-secretase
OtherAbstract: Compounds of formula (I) are disclosed: wherein R is an alkenyl group of defined structure. The compPalabras claves:Autores:Harrison CastroFuentes:googleEffect of single doses of inhaled lignocaine on FEV1 and bronchial reactivity in asthma
OtherAbstract: Inhaled lignocaine appeared to have considerable steroid sparing properties in an uncontrolled trialPalabras claves:Autores:Harrison CastroFuentes:googleEfficacy and Mechanism Evaluation
OtherAbstract: A randomised, double-blind, placebo-controlled study to evaluate the efficacy of oral azithromycin aPalabras claves:Autores:Harrison CastroFuentes:googleDifferential Methylation of Plasma Cell Free DNA: A Potential Asthma Biomarker?
OtherAbstract: Rationale Making a correct diagnosis of asthma is difficult. Methacholine testing is only availablePalabras claves:Autores:Harrison CastroFuentes:google