Documentos de Harrison Castro

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Mostrando 10 resultados de: 13

4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure−Activity Relationships and in Vivo Activity

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Abstract: Previously reported studies from these laboratories described the design of a novel series of high-a

7-(1, 1-Dimethylethyl)-6-(2-ethyl-2 H-1, 2, 4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1, 2, 4-triazolo [4, 3-b] pyridazine: A Functionally Selective γ-Aminobutyric AcidA (GABAA …

Other

Abstract: There is increasing evidence that compounds with selectivity for γ-aminobutyric acidA (GABAA) α2- an

DEUBIQUITINASES AND THEIR INHIBITORS: CHALLENGES AND RECENT ADVANCES

Catalytic site-directed γ-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and β-APP cleavages

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Abstract: The generation of γ-secretase inhibitors which block the release of β-amyloid peptide (Aβ) has long

Acid-promoted reaction of cyclic allylic diols with carbonyl compounds. Stereoselective ring-enlarging tetrahydrofuran annulations

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Abstract: Results Preparation of Cyclic Allylic Diols. The 1-alkenyl-1, 2-cycloalkanediol starting materials a

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5 …

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Abstract: Novel benzodiazepine-containing γ-secretase inhibitors for potential use in Alzheimer's disease have

General approach to halogenated tetrahydrofuran natural products from red algae of the genus Laurencia. Total synthesis of (.+-.)-trans-kumausyne and demonstration of an …

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Abstract: A general strategy for the synthesis of C15 halogenated tetrahydrofuranoid lipids from red algae of

New Synthesis of 1,3-Dihydro-1,4-benzodiazepin-2(2H)-ones and 3-Amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones: Pd-Catalyzed Cross-Coupling of Imidoyl …

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Abstract: A new approach to the synthesis of 1,4-benzodiazepines and 3-amino-1,4-benzodiazepines, which employ

Novel orally bioavailable γ-secretase inhibitors with excellent in vivo activity

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Abstract: The development of potent γ-secretase inhibitors having substituted heterocycles attached to a benzo

In vitro characterization of the presenilin-dependent γ-secretase complex using a novel affinity ligand

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Abstract: γ-Secretase is the enzyme activity releasing the amyloid-β peptide from membrane-bound processing in

Mostrando 10 resultados de: 13

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4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure−Activity Relationships and in Vivo Activity

7-(1, 1-Dimethylethyl)-6-(2-ethyl-2 H-1, 2, 4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1, 2, 4-triazolo [4, 3-b] pyridazine: A Functionally Selective γ-Aminobutyric AcidA (GABAA …

DEUBIQUITINASES AND THEIR INHIBITORS: CHALLENGES AND RECENT ADVANCES

Catalytic site-directed γ-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and β-APP cleavages

Acid-promoted reaction of cyclic allylic diols with carbonyl compounds. Stereoselective ring-enlarging tetrahydrofuran annulations

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5 …

General approach to halogenated tetrahydrofuran natural products from red algae of the genus Laurencia. Total synthesis of (.+-.)-trans-kumausyne and demonstration of an …

New Synthesis of 1,3-Dihydro-1,4-benzodiazepin-2(2H)-ones and 3-Amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones: Pd-Catalyzed Cross-Coupling of Imidoyl …

Novel orally bioavailable γ-secretase inhibitors with excellent in vivo activity

In vitro characterization of the presenilin-dependent γ-secretase complex using a novel affinity ligand