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European Journal of Medicinal Chemistry(1)
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Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist
ArticleAbstract: Kappa opioid receptor (KOPr) agonists represent alternative analgesics for their low abuse potentialPalabras claves:antinociception, chemotherapy-induced neuropathic pain, functional selectivity, intracellular signaling, kappa opioid receptorAutores:Baiula M., Bedini A., De Marco R., Di Cesare Mannelli L., Gabriela Vaca Altamirano, Gentilucci L., Ghelardini C., Micheli L., Spampinato S.Fuentes:scopusIndazolylketones as new multitarget cannabinoid drugs
ArticleAbstract: Multitarget cannabinoids could be a promising therapeutic strategic to fight against Alzheimer's disPalabras claves:Alzheimer's disease, BACE-1 inhibitor, BuChE inhibitor, CB2R agonist, Indazolylketone, Multitarget drugAutores:Campillo N.E., de Ceballos M.L., Gabriela Vaca Altamirano, Girón R., González-Naranjo P., Martín-Fontelles M.I., Martin-Requero Á., Páez J.A., Pérez C., Pérez-Macias N., Roca C., Sánchez-Robles E.Fuentes:scopusTherapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)
ArticleAbstract: TDP-43 has been identified as the major component of protein aggregates found in affected neurons inPalabras claves:ALS, CDC-7 inhibitors, FTLD-TDP, lymphoblasts, TDP-43Autores:Cuevas E.P., Fernandez A., Gabriela Vaca Altamirano, Gil C., Martin-Requero Á., Martinez A., Martinez-Gonzalez L., Porras G., Rojas-Prats E.Fuentes:scopus