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Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8
ArticleAbstract: Certain effects of melatonin on senescence were investigated. The experimental model used was 10-monPalabras claves:aging, ck5/p35, GSK3β, Oxidative Stress, SAMP8, TauAutores:Antoni Camins, Caballero B., Canudas A.M., Coto-Montes A., Gutiérrez-Cuesta J., Pallás M., Romeu M., Sureda F.X.Fuentes:scopusAn evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis
ArticleAbstract: The neuroprotective effects of melatonin in an experimental model of aging-induced apoptosis have bePalabras claves:aging, cell cycle, Neurodegeneration, P53Autores:Antoni Camins, Pallás M., Pelegrí Gabalda C., Tajes Orduña M., Vilaplana J.Fuentes:scopusAnti-aging properties of melatonin in an in vitro murine senescence model: Involvement of the sirtuin 1 pathway
ArticleAbstract: Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerabPalabras claves:ADAM10, aging, Neurodegeneration, NFκB, Oxidative Stress, P53Autores:Antoni Camins, Gutiérrez-Cuesta J., Ortuo-Sahagún D., Pallás M., Tajes M.Fuentes:scopusFavorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice
ArticleAbstract: Senescence-accelerated mice (SAMP8) and senescence-accelerated resistant mice (SAMR1) were studied aPalabras claves:aging, BRAIN, Melatonin receptor-1, Neurofibrillary tangle, Nuclear factor-kappa B, Retinoic acid receptor-related orphan receptor-α1, Senescence-accelerated miceAutores:Antoni Camins, Caballero B., Coto-Montes A., Gonzalo-Calvo D.D., Gutiérrez-Cuesta J., Huidobro-Fernández C., Pallás M., Rodríguez-Colunga M.J., Sierra V., Soria-Valles C., Tolivia D., Vega-Naredo I.Fuentes:scopusEvaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model
ArticleAbstract: We examined the effect of melatonin on pro-survival processes in three groups of mice. Untreated senPalabras claves:aging, Amyloid β, BRAIN, Cysteine proteases, Sirt1Autores:Antoni Camins, Coto-Montes A., Gutiérrez-Cuesta J., Jiménez A., Pallás M., Tajes M.Fuentes:scopusNeurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol
ArticleAbstract: The senescence-accelerated prone 8 (SAMP8) mouse strain shows early cognitive loss that mimics the dPalabras claves:aging brain, melatonin, Mitochondria, Resveratrol, SAMP8 mouse neuron cultures, Sirtuin 1Autores:Antoni Camins, Corpas R., Coto-Montes A., Cristòfol R., Pallás M., Porquet D., Sanfeliu C., Serret J.Fuentes:scopusInhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease
ArticleAbstract: In this study, the effects of melatonin on MPP+-treated cerebellar granule neurons (CGNs) in culturePalabras claves:apoptosis, Calpain, caspase, CDK5, Cerebellar granule cells, MPP +Autores:Acuña-Castroviejo D., Alvira D., Antoni Camins, Folch J., Pallás M., Tajes M., Verdaguer E.Fuentes:scopusMelatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice
ArticleAbstract: We studied the effect of age and melatonin on cell death processes in brain aging. Senescence-accelePalabras claves:aging, apoptosis, Autophagy, Calpains, Caspases, Cathepsins, melatoninAutores:Antoni Camins, Caballero B., Coto-Montes A., Gonzalo-Calvo D.D., Huidobro-Fernández C., Pallás M., Rodríguez-Colunga M.J., Sierra V., Soria-Valles C., Tolivia D., Vega-Naredo I.Fuentes:scopusThe antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes
ArticleAbstract: A potential application of melatonin is its ability to rescue many cell types from cell death, becauPalabras claves:apoptosis, B65, cell cycle, melatonin, NeuroblastomaAutores:Antoni Camins, Esparza J.L., Folch J., Pallás M., Pizarro J.G., Verdaguer E., Yeste-Velasco M.Fuentes:scopus