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2019 IEEE 4th Ecuador Technical Chapters Meeting, ETCM 2019(2)
Biochemical and Biophysical Research Communications(2)
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Analysis of DNA Polymerases Reveals Specific Genes Expansion in Leishmania and Trypanosoma spp.
ArticleAbstract: Leishmaniasis and trypanosomiasis are largely neglected diseases prevailing in tropical and subtropiPalabras claves:DNA polymerases, DNA repair, gene amplification, genome stability, translesion synthesis, trypanosomatidsAutores:Ana Maria Poveda, Miguel Angel Méndez, Vinicio Danilo Armijos-JaramilloFuentes:googlescopusAnemia in women of reproductive age in Ecuador: Data from a national survey
ArticleAbstract: Background Anemia is a condition characterized by a decline in the number of functional red blood cePalabras claves:Autores:Andrea Sosa-Moreno, Miguel Angel Méndez, Sharon Reinoso-GonzalezFuentes:scopusA review on the information content of the pair density as a tool for the description of the electronic properties in molecular systems
ReviewAbstract: Recent advances on the use of the information content of the pair density to understand bonding andPalabras claves:electron localization, Kullback-Leibler divergence, pair density, Reaction forceAutores:César H. Zambrano, Fernando Javier Torres, Jose R. Mora, Luis Rincon, Miguel Angel MéndezFuentes:scopusA theoretical study of the conformational preference of alkyl-and aryl-substituted pyrogallol[4]arenes and evidence of the accumulation of negative electrostatic potential within the cavity of their rccc conformers
ArticleAbstract: We report a theoretical study of the structural and electronic properties of the rccc and rctt confoPalabras claves:conformational preference, DFT, Electrostatic potential, Macromolecules, PyrogallolAutores:César H. Zambrano, Dueno E.E., Fernando Javier Torres, Miguel Angel Méndez, Robert A. Cazar, Sebastián ManzanoFuentes:scopusFluorescence of unmodified oligonucleotides: A tool to probe G-quadruplex DNA structure
ArticleAbstract: Fluorescence of unmodified oligonucleotides has not been exploited for guanine-quadruplex (G-quadrupPalabras claves:Exciplex, Guanine, Quadruplex fluorescenceAutores:Miguel Angel Méndez, Szalai V.A.Fuentes:googlescopusEnd-stacking of copper cationic porphyrins on parallel-stranded guanine quadruplexes
ArticleAbstract: Nucleic acids that contain multiple sequential guanines assemble into guanine quadruplexes (G-quadruPalabras claves:Copper porphyrin, End-stacking, Fourier transform ion cyclotron resonance mass spectrometry and electron paramagnetic resonance spectroscopy, Guanine quadruplex, Guanine quartetAutores:Evans S.E., Grimes R.T., Keating L.R., Melchoir S., Miguel Angel Méndez, Szalai V.A., Turner K.B.Fuentes:googlescopusDiscovering key residues of dengue virus NS2b-NS3-protease: New binding sites for antiviral inhibitors design
ArticleAbstract: The NS2B-NS3 protease is essential for the Dengue Virus (DENV) replication process. This complex conPalabras claves:Bindability sites, Computational alanine scanning mutagenesis, Dengue Virus, DENV NS2b-NS3 protease, Machine learning, Multilayer Perceptron, Protease inhibitorAutores:D. Mollocana, Daniel Aguilera-Pesantes, Fernando Javier Torres, L. E. Robayo, Miguel Angel Méndez, P. E. Méndez, Yovani Marrero-PonceFuentes:scopusOptical biosensor for in situ metabolite quantification in plant leaves
Conference ObjectAbstract: We present a strategy based on the optical properties of the G-cuadruplex DNA-bound NMM IX dye to suPalabras claves:Autores:Andrea Montero-Oleas, Briggitte Leon, Cesar Costa-Vera, Miguel Angel Méndez, Torres M.L.Fuentes:scopusMean residence time by hierarchical clustering analysis
ArticleAbstract: A revised method, based on the hierarchical clustering data analysis technique, is proposed as an imPalabras claves:Data Analysis, hierarchical clustering, Mean residence time, molecular dynamics, Molecular engineering, MRI contrast agentAutores:C. V. del Hierro, Dennis Cazar Ramirez, Fernando Javier Torres, L. Guzzardi, Miguel Angel MéndezFuentes:googlescopusInteraction of ZIKV NS5 and STAT2 Explored by Molecular Modeling, Docking, and Simulations Studies
Conference ObjectAbstract: ZIKV NS5 has been associated with inhibition of type I IFN during the host antiviral response. The pPalabras claves:docking, molecular dynamics, NS5, STAT2, Zika VirusAutores:Fernando Javier Torres, Gerardo Armijos-Capa, Miguel Angel Méndez, Paúl Pozo-GuerrónFuentes:googlescopus