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Molecular and Cellular Endocrinology(5)
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scopus(18)
Cofactors, redox state, and directional preferences of hydroxysteroid dehydrogenases
ReviewAbstract: The hydroxysteroid dehydrogenases (HSDs) interconvert pairs of weak and potent steroids, thus servinPalabras claves:androgen, Equilibrium, Estrogen, Glucocorticoid, Hydroxysteroid dehydrogenase, Nicotinamide cofactor, Redox stateAutores:Agarwal A.K., Andersson S., Brandmaier A., Chattopadhyay A., Khan N., Papari-Zareei M., Rambally S., Richard J. Auchus, Sharma K.K., Sherbet D.P.Fuentes:scopusAndrogen biosynthesis and gene defects
Book PartAbstract: Formation of the male external genitalia in human beings requires the production of dihydrotestosterPalabras claves:androgen, Cytochrome p450, Dehydrogenase, Dihydrotestosterone, Disorder of sex development, External genitalia, Hydroxysteroid, Hypogonadism, steroidogenesis, Testis, Testosterone, VirilizationAutores:Richard J. Auchus, Turcu A.F.Fuentes:scopusAndrogens, estrogens, and hydroxysteroid dehydrogenases
ReviewAbstract: The task of regulating both production and activity of potent androgens and estrogens in human physiPalabras claves:androgen, Equilibrium, Estrogen, Glucocorticoid, Hydroxysteroid dehydrogenase, Nicotinamide cofactor, Redox stateAutores:Mizrachi D., Richard J. AuchusFuentes:scopus46,XX DSD: The masculinised female
ReviewAbstract: The 46,XX disorders of sex development (DSDs) cause virilisation or masculinisation of the female foPalabras claves:46,XX DSD, Adrenal gland, androgen, Congenital adrenal hyperplasia, steroidogenesis, VirilisationAutores:Chang A.Y., Richard J. AuchusFuentes:scopusA-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone
ArticleAbstract: Abiraterone acetate is a potent inhibitor of human cytochrome P450c17 (CYP17A1, 17α-hydroxylase/17,2Palabras claves:abiraterone, androgen, CYP17A1, Cytochrome p450, Enzymology, Prostate cancer, steroidogenesisAutores:Bratoeff E., Garrido M., Peng H.M., Richard J. Auchus, Upadhyay S.K., Yoshimoto F.K.Fuentes:scopusCongenital adrenal hyperplasia in adults
ReviewAbstract: Purpose of Review: Patients born with congenital adrenal hyperplasia (CAH), the majority of which isPalabras claves:21-hydroxylase deficiency, 46XX DSD, Adrenal gland, androgen, Congenital adrenal hyperplasia, steroidogenesis, Testicular adrenal rest tissue, VirilizationAutores:Richard J. AuchusFuentes:scopusDefects in androgen biosynthesis causing 46,XY disorders of sexual development
ArticleAbstract: At least one genetic defect in each reaction of the classical androgen biosynthesis pathway has beenPalabras claves:46 XY DSD, androgen, Congenital adrenal hyperplasia, Enzyme, Steroid, steroidogenesis, Testis, TestosteroneAutores:Miller W.L., Richard J. AuchusFuentes:scopusAdrenal Steroidogenesis and Congenital Adrenal Hyperplasia
ReviewAbstract: Adrenal steroidogenesis is a dynamic process, reliant on de novo synthesis from cholesterol, under tPalabras claves:21-hydroxylase, Adrenal insufficiency, Ambiguous genitalia, androgen, Congenital adrenal hyperplasia, Disorder of sex development, Steroid hydroxylase, steroidogenesisAutores:Richard J. Auchus, Turcu A.F.Fuentes:scopusExpression in escherichia coli, purification, and functional reconstitution of human steroid 5α-reductases
ArticleAbstract: The potent androgen 5α-dihydrotestosterone irreversibly derives from testosterone via the activity oPalabras claves:5α-reductase, androgen, Dihydrotestosterone, prostate, steroidogenesisAutores:Han B., Im S.C., Liu J., Peng H.M., Qiao J., Richard J. Auchus, Valentín-Goyco J.Fuentes:scopusFertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): Combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency
ReviewAbstract: CYP17A1 catalyzes the 17-hydroxylase and 17,20-lyase reactions, regulating the steroid hormones prodPalabras claves:17-hydroxylase/17,20-lyase, 46,XY DSD, androgen, Hypertension, Infertility, mineralocorticoid, primary amenorrhea, sexual infantilismAutores:Marsh C.A., Richard J. AuchusFuentes:scopus