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Circulating 11-oxygenated androgens across species
ArticleAbstract: The androgen precursors, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are produced in highPalabras claves:11-oxyandrogens, Adrenal, Primates, steroidsAutores:Conley A.J., Elsey R.M., Garber S., Rainey W.E., Rege J., Richard J. Auchus, Turcu A.F.Fuentes:scopusComparison of the hamster and human adrenal P450c17 (17α-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling
ArticleAbstract: In order to understand the activity specificity of the hamster cytochrome P450 17α-hydroxylase/17,20Palabras claves:17,20-Lyase, 17α-hydroxylase, 3D modeling, Adrenals, CYP17, Cytochrome P450c17, HÁMSTER, Human, Mutants, Site-directed mutagenesisAutores:LeHoux J.G., Mathieu A.P., Richard J. AuchusFuentes:scopusA high rate of novel CYP11B1 mutations in Saudi Arabia
ArticleAbstract: Despite ethnic variation, 11 β-hydroxylase deficiency (11β-OHD) has generally been considered the sePalabras claves:Ambiguous genitalia, Congenital adrenal hyperplasia, CYP11B1, MutationsAutores:Al-Sagheir A., Alhomaidah D., Alswailem M., Alzahrani A., Alzahrani O., Bin-Abbas B., Capper C.P., Murugan A., Qasem E., Richard J. AuchusFuentes:scopusA-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone
ArticleAbstract: Abiraterone acetate is a potent inhibitor of human cytochrome P450c17 (CYP17A1, 17α-hydroxylase/17,2Palabras claves:abiraterone, androgen, CYP17A1, Cytochrome p450, Enzymology, Prostate cancer, steroidogenesisAutores:Bratoeff E., Garrido M., Peng H.M., Richard J. Auchus, Upadhyay S.K., Yoshimoto F.K.Fuentes:scopusDevelopment and validation of a novel LC–MS/MS method for simultaneous determination of abiraterone and its seven steroidal metabolites in human serum: Innovation in separation of diastereoisomers without use of a chiral column
ArticleAbstract: Abiraterone acetate (AA), the prodrug of abiraterone, is FDA-approved for the treatment of castratioPalabras claves:abiraterone, LC–MS/MS, Metabolites, Method validation, Prostate cancerAutores:Alyamani M., Anderson D., Li Z., Richard J. Auchus, Sharifi N., Upadhyay S.K.Fuentes:scopusCatalytic modulation of human cytochromes P450 17A1 and P450 11B2 by phospholipid
ArticleAbstract: Unlike most of the drug-metabolizing cytochrome P450s, microsomal P450 17A1 and mitochondrial P450 1Palabras claves:P450 11B2, P450 17A1, phospholipidAutores:Barlow C., Peng H.M., Richard J. AuchusFuentes:scopusAdrenocortical carcinoma in a 17th-century girl
ReviewAbstract: Adrenocortical carcinoma (ACC) is a rare, often fatal disease, that may be seen sporadically or withPalabras claves:Adrenal, AUTOPSY, Cáncer, Cushing syndrome, PediatricsAutores:Else T., Miller W.L., Richard J. AuchusFuentes:scopusFunctional characterization of the G162R and D216H genetic variants of human CYP17A1
ArticleAbstract: Cytochrome P450 17A1 (CYP17A1) is a dual-function enzyme catalyzing reactions necessary for cortisolPalabras claves:CYP17A1, Cytochrome p450, Proteasome, steroidogenesis, UbiquitinationAutores:Capper C.P., Hollenberg P.F., Johnson M.D., Larios J.M., Liu J., McIntosh L.R., Osawa Y., Rae J.M., Richard J. AuchusFuentes:scopusIntratumoral steroid profiling of adrenal cortisol-producing adenomas by liquid chromatography- mass spectrometry
ArticleAbstract: Endogenous Cushing syndrome (CS) is an endocrine disorder marked by excess cortisol production rendePalabras claves:Cortisol-producing adenoma, LC–MS/MS, Mild autonomous cortisol excess, OCT-embedded tissue, Overt Cushing syndrome, Steroid profilingAutores:Chen X., Else T., Nanba K., Rainey W.E., Rege J., Richard J. Auchus, Teuber J.P., Turcu A.F., Zhao L.Fuentes:scopusIntroduction to the 2018 Keith L. Parker Award Lecture, William E. Rainey, PhD
ReviewAbstract: The Adrenal Cortex Meeting celebrated the awarding of the Keith L. Parker Award Lecture to William EPalabras claves:Adrenal, aldosterone, Androgens, transcription, ZonationAutores:Richard J. AuchusFuentes:scopus