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Cofactors, redox state, and directional preferences of hydroxysteroid dehydrogenases
ReviewAbstract: The hydroxysteroid dehydrogenases (HSDs) interconvert pairs of weak and potent steroids, thus servinPalabras claves:androgen, Equilibrium, Estrogen, Glucocorticoid, Hydroxysteroid dehydrogenase, Nicotinamide cofactor, Redox stateAutores:Agarwal A.K., Andersson S., Brandmaier A., Chattopadhyay A., Khan N., Papari-Zareei M., Rambally S., Richard J. Auchus, Sharma K.K., Sherbet D.P.Fuentes:scopusAndrogens, estrogens, and hydroxysteroid dehydrogenases
ReviewAbstract: The task of regulating both production and activity of potent androgens and estrogens in human physiPalabras claves:androgen, Equilibrium, Estrogen, Glucocorticoid, Hydroxysteroid dehydrogenase, Nicotinamide cofactor, Redox stateAutores:Mizrachi D., Richard J. AuchusFuentes:scopusDeoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues
Conference ObjectAbstract: Aldosterone is the principal endogenous mineralocorticoid in humans and regulates salt and water homPalabras claves:AKR1C3, COLON, Doc, Human, inactivation, Kidney, mineralocorticoidAutores:Andersson S., Lindqvist A., Penning T.M., Richard J. Auchus, Sharma K.K., Zhou X.J.Fuentes:scopusGerm cell neoplasia in situ complicating 17β-hydroxysteroid dehydrogenase type 3 deficiency
ReviewAbstract: 17β-hydroxysteroid dehydrogenase type 3 (17βHSD3)deficiency is an autosomal recessive disorder of maPalabras claves:17β-hydroxysteroid dehydrogenase type 3 deficiency, 46XY disorder of sex development, Mutations, Puberty, Testosterone, VirilizationAutores:Eugster E.A., Folsom L.J., Hjaige M., Liu J., Richard J. AuchusFuentes:scopusElectrochemistry of cytochrome P450 17α-hydroxylase/17,20-lyase (P450c17)
ReviewAbstract: Within the superfamily of cytochrome P450 enzymes (P450s), there is a small class which is functionaPalabras claves:adrenal cortex, androgen, CYP17A1, Cytochrome P450c17, Direct electrochemistry, electron transfer, mechanism, steroidogenesisAutores:Bond A.M., Conley A.J., Corbin C.J., Kubeil C., Kuznetsov V.L., Martin L.L., Richard J. Auchus, Rodgers R.J., Simonov A.N.Fuentes:scopusManagement considerations for the adult with congenital adrenal hyperplasia
ReviewAbstract: The congenital adrenal hyperplasias (CAH) are a group of genetic defects in cortisol biosynthesis, mPalabras claves:21-hydroxylase deficiency, Adrenal gland, androgen, Congenital adrenal hyperplasia, steroidogenesis, Testicular adrenal rest tumorAutores:Richard J. AuchusFuentes:scopusMass spectrometry theory and application to adrenal diseases
ReviewAbstract: The diagnosis and management of adrenal diseases hinge upon accurate determination of hormone concenPalabras claves:adrenal glands, Congenital adrenal hyperplasia, Mass spectrometry, Multiple reaction monitoring, pathways, SteroidAutores:Richard J. Auchus, Wooding K.M.Fuentes:scopusIntroduction to the 2012 Keith L. Parker Memorial Lecturer: Walter L. Miller, MD
ReviewAbstract:Palabras claves:Bovine growth hormone, Lipoid congenital adrenal hyperplasia, molecular biology, P450-oxidoreductase deficiency, steroidogenesisAutores:Richard J. AuchusFuentes:scopusSteroid 5α-reductase 1 promotes 5α-androstane-3α, 17β-diol synthesis in immature mouse testes by two pathways
ArticleAbstract: 5α-Androstane-3α,17β-diol (androstanediol) is the predominant androgen in immature mouse testes, andPalabras claves:17β-(N,N-diethyl)carbamoyl-4-methyl-4-aza-5α-androstan-3-one, 4MA, 5α-androstane-3α,17β-diol, Androstanediol, High-performance liquid chromatography, HPLC, Mouse testes, Neonatal androgen, Steroid 5α-reductaseAutores:Mahendroo M., Richard J. Auchus, Richardson J., Wilson J.D.Fuentes:scopusStrategies that athletes use to avoid detection of androgenic-anabolic steroid doping and sanctions
ArticleAbstract: Androgenic-anabolic steroids (AAS) are potent and widely used performance-enhancing substances (PES)Palabras claves:androgen, Designer steroid, Diuretic, Doping, Masking, Therapeutic use exemptionAutores:Alquraini H., Richard J. AuchusFuentes:scopus