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Article(5)
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Proceedings of the National Academy of Sciences of the United States of America(3)
Chemistry - A European Journal(1)
FEBS Journal(1)
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
ArticleAbstract: The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat toPalabras claves:acetohydroxyacid synthase, Antifungal drug, Candida Albicans, Crystal structure, HerbicideAutores:Agnew-Francis K., Chua S.M.H., Fraser J.A., Guddat L.W., Lee Y.T., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Nouwens A., Wang J.G., Williams C.M.Fuentes:googlescopusComprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families
ArticleAbstract: Five commercial herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which isPalabras claves:acetohydroxyacid synthase, Acetolactate synthase, Crystal structure, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Nouwens A.Fuentes:googlescopusCrystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity
ArticleAbstract: Ketol-acid reductoisomerase (KARI) is an NAD(P)H and Mg2+-dependent enzyme of the branched-chain amiPalabras claves:branched-chain amino acid biosynthesis, Drug Discovery, Herbicide, ketol-acid reductoisomerase, transition state analogueAutores:David A. Terán, Guddat L.W., Kandale A., Lv Y., Mario Daniel García, McGeary R.P., Patel K.M., Schembri M.A., Schenk G., Zheng S.Fuentes:scopusCrystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides
ArticleAbstract: Acetohydroxyacid synthase (AHAS, EC 2.2.1.6) is the first enzyme in the branched-chain amino acid biPalabras claves:acetohydroxyacid synthase, Acetolactate synthase, Herbicide, inhibitor, thiamine diphosphateAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Wang J.G.Fuentes:googlescopusStructural insights into the mechanism of inhibition of AHAS by herbicides
ArticleAbstract: Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway,Palabras claves:acetohydroxyacid synthase, Crystal structure, FAD, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Mobli M., Nouwens A., Pierens G.Fuentes:googlescopus