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Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
ArticleAbstract: The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat toPalabras claves:acetohydroxyacid synthase, Antifungal drug, Candida Albicans, Crystal structure, HerbicideAutores:Agnew-Francis K., Chua S.M.H., Fraser J.A., Guddat L.W., Lee Y.T., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Nouwens A., Wang J.G., Williams C.M.Fuentes:googlescopusHigh Resolution Crystal Structures of the Acetohydroxyacid Synthase‐Pyruvate Complex Provide New Insights into Its Catalytic Mechanism
OtherAbstract: Acetohydroxyacid synthase (AHAS) is the first enzyme in the biosynthesis pathway of the branched‐chaPalabras claves:Autores:Mario D. GarciaFuentes:googleIdentificación de inhibidores de las enzimas RdRp y Mpro del virus SARS-CoV-2 mediante homología estructural. Revis Bionatura 2023; 8 (1) 26
OtherAbstract:Palabras claves:Autores:Mario D. GarciaFuentes:googleSusceptibility analysis of mutations that confer resistance to inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)
OtherAbstract: Enormous efforts have been made worldwide to generate therapeutic options to prevent the transmissibPalabras claves:Autores:Mario D. GarciaFuentes:googleThe 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements
ArticleAbstract: Acetohydroxyacid synthase (AHAS) catalyzes the first step of branched-chain amino acid biosynthesis,Palabras claves:Autores:Fraser J.A., Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Williams C.M.Fuentes:googlescopusThe role of a FAD cofactor in the regulation of acetohydroxyacid synthase by redox signaling molecules
ArticleAbstract: Acetohydroxyacid synthase (AHAS) catalyzes the first step of branched-chain amino acid (BCAA) biosynPalabras claves:Autores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel GarcíaFuentes:googlescopusTriazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads
ArticleAbstract: Aspergillus fumigatus is a fungal pathogen whose effects can be debilitating and potentially fatal iPalabras claves:Autores:Fraser J.A., Guddat L.W., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Schenk G.Fuentes:googlescopus