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Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates
ArticleAbstract: The cytochrome P450 family 1 enzymes (CYP1s) are a diverse family of hemoprotein monooxygenases, whiPalabras claves:ancestral sequence reconstruction, CYP1A2, CYP1B1, Cytochrome p450, drug metabolism, thermostabilityAutores:Andersson S., Boden M., Foley G., Gillam E.M.J., Gumulya Y., Harris K.L., Janosik T., Jurva U., Sandinge A.S., Saskya E. Carrera-Pacheco, Syed P., Thomson R.E.S.Fuentes:scopusEngineering functional thermostable proteins using ancestral sequence reconstruction
ReviewAbstract: Natural proteins are often only slightly more stable in the native state than the denatured state, aPalabras claves:ancestral sequence reconstruction, Biocatalysis, Cytochrome p450, directed evolution, Molecular evolution, precambrian, protein engineering, Synthetic biology, thermostabilityAutores:Gillam E.M.J., Saskya Carrera, Saskya E. Carrera-Pacheco, Thomson R.E.S.Fuentes:googlescopusEvaluation of Biological Activity of Natural Compounds: Current Trends and Methods
ReviewAbstract: Natural compounds have diverse structures and are present in different forms of life. Metabolites suPalabras claves:Antimicrobial, antioxidant, bioactive compounds, Natural productAutores:Arianna Mayorga-Ramos, Benjamín Arias-Almeida, Carlos Barba-Ostria, Cristina Rodríguez-Pólit, Johana Zúñiga-Miranda, Jorge Hebkp_redia-Moya, Linda P. Guamán, REBECA GONZALEZ-PASTOR, Saskya E. Carrera-PachecoFuentes:scopus