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C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer's disease targeting tauopathies
ArticleAbstract: Protein phosphatase 2A (PP2A) is an important Ser/Thr phosphatase that participates in the regulatioPalabras claves:Alzheimer's disease, neuroprotection, Okadaic acid, PP2A-activating drug (PAD), Protein phosphatase 2A (PP2A), TauopathiesAutores:Arribas R.L., de los Ríos C., García-Frutos E.M., Isaac Bravo, Janssens V., Martínez M., Montiel C., Ramos E., Romero A., Viejo L.Fuentes:scopusPolyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment
ArticleAbstract: Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activatorPalabras claves:Antioxidants, butyrylcholinesterase, free radical scavengers, neuroprotection, α-phenyl-tert-butyl(benzyl)nitronesAutores:de los Ríos C., Diez-Iriepa D., Gobec S., Hadjipavlou-Litina D., Iriepa I., Isaac Bravo, Knez D., López-Muñoz F., Marco-Contelles J.Fuentes:scopus