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Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction
ArticleAbstract: Therapies aimed at enhancing cardiomyocyte survival following myocardial injury are urgently requirePalabras claves:Cardioprotection, Growth-hormone-releasing peptide 6 (GHRP6), infarction, Ischaemia, myocardium, Necrosis, Oxidative StressAutores:Alba J., Berlanga-Acosta J., Cibrian D., Dominguez H., Garcia D., Guevara L., Guillén-Nieto G.E., López-Mola E., López-Saura P.A., Perez B., Rodriguez A., Santiago Nelson Vispo, Seralena A.Fuentes:scopusHydrogel for the Controlled Delivery of Bioactive Components from Extracts of Eupatorium glutinosum Lam. Leaves
ArticleAbstract: This research reported a hydrogel loaded with the ethanolic and methanolic extracts of Eupatorium glPalabras claves:anti-hemolytic activity, Antibacterial activity, Antioxidant activity, controlled delivery system, secondary metabolitesAutores:Antonio Machado, Frank Alexis, Jose R. Mora, Lizbeth Zamora-Mendoza, Lola De Lima, Santiago Nelson VispoFuentes:googlescopusExpression and Characterization of Human Vascular Endothelial Growth Factor Produced in SiHa Cells Transduced with Adenoviral Vector
ArticleAbstract: The vascular endothelial growth factor (VEGF) is an essential factor to pathologic angiogenesis. DisPalabras claves:Adenoviral vector, ECV-304 cells, HUVEC, Vascular permeability, VEGF 121Autores:Aedo G., Camacho F., Castillo C., González-Chavarría I., González-Horta E.E., Mansilla R., Parra N.C., Sanchez O., Santiago Nelson VispoFuentes:scopusExpression and folding of an interleukin-2-proinsulin fusion protein and its conversion into insulin by a single step enzymatic removal of the C-peptide and the N-terminal fused sequence
ArticleAbstract: We report the expression in E. coli of a proinsulin fusion protein carrying a modified interleukin-2Palabras claves:Enzymatic processing, Proinsulin folding, Recombinant insulinAutores:Besada-Pérez V., Castellanos‐Serra L., Eugenio Hardy, Falcón-Cama V., Fernandez C., Gonzalez M., Herrera L., Perez G., Santiago Nelson Vispo, Santos-Savio A., Silva A., Ubieta R.Fuentes:scopusExpression of il-2/proinsulin fusion protein: Folding of the fusion protein and conversion into insulin by a one step removal of c-peptide and leader sequence
ArticleAbstract:Palabras claves:Autores:Besada-Pérez V., Castellanos L.R., Estrada R., Eugenio Hardy, Fernandez C., Gonzalez M., Herrera L., Jimenez V., Perez G., Santiago Nelson Vispo, Silva A., Ubieta R.Fuentes:scopusForms and methods for interferon’s encapsulation
ReviewAbstract: Interferons (IFNs) are cytokines involved in the immune response that act on innate and adaptive immPalabras claves:Antiproliferative, antiviral, Drug delivery system, Encapsulate IFNs, formulation, IFN-α, IFN-β, IFN-γ, Immunomodulator, interferons, Liposomes, Microparticles, Nanoparticles, Pegylation, Polymeric micellesAutores:Leandro Santiago Padilla, Parra N.C., Santana S.P., Santiago Nelson Vispo, Thelvia I. Ramos Gómez, Toledo Alonso J.R., Villacis-Aguirre C.A.Fuentes:googlescopusGene therapy using a plasmid that expresses the VEGF<inf>121</inf> for the treatment of the critical ischemic cardiophaty
ArticleAbstract: Here we report, for the first time in Cuba, the use of gene therapy to evaluate the positive therapePalabras claves:Clinical study, Gene therapy, Vascular endothelial growth factorAutores:Batista J.F., Betancourt B.Y., Chaos N., Chil R., Coca M., Fleites G., García A., García E., Garzón E., González M.J., González N., González R., Guevara L., Guillén-Nieto G.E., Méndez T., Milán R., Naffe M., Quián Y.P., Reina C., Santiago Nelson Vispo, Senra G., Seralena A., Suárez L.R., Vazquez R., Villar A.Fuentes:scopusCharacterization of epitopes on human interleukin-2 using phage displayed-peptide libraries: Insights into antibody-peptide interactions
ArticleAbstract: We have characterized the binding epitopes of two monoclonal antibodies (MAbs) reacting with human IPalabras claves:Autores:Araña M.J., Cesareni G., Chinea G., Ojalvo A.G., Santiago Nelson VispoFuentes:scopusChemical Conjugation in Drug Delivery Systems
ReviewAbstract: Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer are usuPalabras claves:Biomolecules, Carriers, covalent bioconjugation, Drug delivery systems, linkersAutores:Alberício F., Alexis Eras, Danna Castillo, Hortensia Rodriguez Cabrera, Santiago Nelson Vispo, Suárez Navarro M.Fuentes:scopusAntitumor effect of a novel proapoptotic peptide that impairs the phosphorylation by the protein kinase 2 (casein kinase 2)
ArticleAbstract: Protein Kinase (casein kinase 2, CK2) is a serine-threonine kinase that is frequently dysregulated iPalabras claves:Autores:Acevedo B.E., Alonso D.F., Falcón-Cama V., López-Mola E., Mendoza O., Perea-Rodríguez S.E., Puchades Y., Reyes O., Santiago Nelson Vispo, Santos-Savio A., Silva R., Torrens I.Fuentes:scopus