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A monoclonal antibody against NeuGc-containing gangliosides contains a regulatory idiotope involved in the interaction with B and T cells
ArticleAbstract: P3 (IgM-κ) is a monoclonal antibody (mAb) reacting with N-glycolyl neuraminic acid (NeuGc)-containinPalabras claves:H-CDR3, Idiotype, Monoclonal antibody, N-Glycolyl neuraminic acidAutores:Mier E., Perez A., Rodríguez R., Santiago Nelson Vispo, Vázquez A.M.Fuentes:scopusCharacterization of epitopes on human interleukin-2 using phage displayed-peptide libraries: Insights into antibody-peptide interactions
ArticleAbstract: We have characterized the binding epitopes of two monoclonal antibodies (MAbs) reacting with human IPalabras claves:Autores:Araña M.J., Cesareni G., Chinea G., Ojalvo A.G., Santiago Nelson VispoFuentes:scopusChemical Conjugation in Drug Delivery Systems
ReviewAbstract: Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer are usuPalabras claves:Biomolecules, Carriers, covalent bioconjugation, Drug delivery systems, linkersAutores:Alberício F., Alexis Eras, Danna Castillo, Hortensia Rodriguez Cabrera, Santiago Nelson Vispo, Suárez Navarro M.Fuentes:scopusAntitumor effect of a novel proapoptotic peptide that impairs the phosphorylation by the protein kinase 2 (casein kinase 2)
ArticleAbstract: Protein Kinase (casein kinase 2, CK2) is a serine-threonine kinase that is frequently dysregulated iPalabras claves:Autores:Acevedo B.E., Alonso D.F., Falcón-Cama V., López-Mola E., Mendoza O., Perea-Rodríguez S.E., Puchades Y., Reyes O., Santiago Nelson Vispo, Santos-Savio A., Silva R., Torrens I.Fuentes:scopusCancer therapies
OtherAbstract:Palabras claves:Autores:Santiago Nelson VispoFuentes:scopusApplication of the Phage Display Technology for the Development of Peptide- mediated Drug Delivery Systems through the Blood-Brain Barrier
ReviewAbstract: The main obstacle to biopharmaceutical delivery in therapeutic concentration into the brain for treaPalabras claves:blood-brain barrier, drug delivery, molecular trojan horse, Phage display technology, receptor-mediated transcytosis, shuttle peptidesAutores:Ramos O.S., Santiago Nelson Vispo, Suárez V.M.Fuentes:scopusDisplay technology on filamentous phage in the searchfor anti-infective biological agents
ReviewAbstract: Introduction: The causes of antibiotic resistance are complex. The phage display technology has beenPalabras claves:Antibodies, Bacteriophages, Biopaning, Combinatorial libraries, Infectious diseases, Peptides, Phage display technologyAutores:Antúnez M.P., Camacho F., Ramos O.S., Santiago Nelson Vispo, Toledo R.Fuentes:scopusDisplaying human interleukin-2 on the surface of bacteriophage
ArticleAbstract: Previous attempts to produce active human Interleukin-2 (hIL-2) in E. coli have failed, due to its aPalabras claves:Interleukin-2, pelB, phage display, Secretion in E. coliAutores:Araña M.J., Callejo M., Chinea G., Gavilondo J.V., Ojalvo A.G., Santiago Nelson Vispo, Santos-Savio A.Fuentes:scopusForms and methods for interferon’s encapsulation
ReviewAbstract: Interferons (IFNs) are cytokines involved in the immune response that act on innate and adaptive immPalabras claves:Antiproliferative, antiviral, Drug delivery system, Encapsulate IFNs, formulation, IFN-α, IFN-β, IFN-γ, Immunomodulator, interferons, Liposomes, Microparticles, Nanoparticles, Pegylation, Polymeric micellesAutores:Leandro Santiago Padilla, Parra N.C., Santana S.P., Santiago Nelson Vispo, Thelvia I. Ramos Gómez, Toledo Alonso J.R., Villacis-Aguirre C.A.Fuentes:googlescopusGangliosides, Ab1 and Ab2 antibodies. I. Towards a molecular dissection of an idiotype-anti-idiotype system
ArticleAbstract: This report is focused on the molecular basis for the interaction of a monoclonal antibody (mAb) andPalabras claves:Anti-idiotypic antibodies, H-CDR, N-Glycolyl-gangliosidesAutores:González M., López-Requena A., Mateo de Acosta C., Moreno E., Pérez R., Puchades Y., Santiago Nelson Vispo, Talavera A., Vázquez A.M.Fuentes:scopus