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Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine
ArticleAbstract: The phosphoramidate triester prodrugs of anti-human HIV 2',3'- dideoxynucleoside analogs (ddN) reprePalabras claves:Autores:Antonio Salgado, Balzarini J., Cahard D., De Clercq E., McGuigan C., Naesens L., Pathirana R., Saboulard D., Velázquez S.Fuentes:scopusComplexation of daclatasvir by single isomer methylated β-cyclodextrins studied by capillary electrophoresis, NMR spectroscopy and mass spectrometry
ArticleAbstract: In capillary electrophoresis an enantioseparation of daclatasvir (DCV) was observed in case of heptaPalabras claves:capillary electrophoresis, Complex stoichiometry, Complex structure, Cyclodextrin-analyte complexation, Mass spectrometry, nuclear magnetic resonance spectroscopyAutores:Antonio Salgado, Benkovics G., Chankvetadze B., Krait S., Malanga M., Naumann L., Neusüß C., Peluso P., Scriba G.K.E., Sohajda T.Fuentes:scopusCapillary electrophoretic and nuclear magnetic resonance studies on the opposite affinity pattern of propranolol enantiomers towards various cyclodextrins
ArticleAbstract: In the present study the migration order of the propranolol enantiomers with various native CDs andPalabras claves:capillary electrophoresis, cyclodextrins, enantiomer migration order, NMR spectroscopy, Propranolol, Separation mechanismsAutores:Antonio Salgado, Chankvetadze B., Crommen J., Fillet M., Lomsadze K., Rousseau A., Servais A.Fuentes:scopusEnantiomeric separation of the antiuremic drug colchicine by electrokinetic chromatography. Method development and quantitative analysis
ArticleAbstract: Two analytical methodologies were developed by CE enabling the enantiomeric separation of colchicinePalabras claves:capillary electrophoresis, colchicine, enantiomer migration order, Enantioseparation, H NMR, QuantitationAutores:Antonio Salgado, Castro-Puyana M., García M.Á., Marina M.L., Menéndez-López N., Valimaña-Traverso J.Fuentes:scopusNovel nucleoside phosphoramidates as inhibitors of HIV: Studies on the stereochemical requirements of the phosphoramidate amino acid
ArticleAbstract: Novel phosphoramidate derivatives of the anti-HIV nucleoside analogue d4T were designed to act as laPalabras claves:d4T, hiv, Nucleotide, Phosphoramidate, Prodrug, Reverse transcriptaseAutores:Antonio Salgado, Balzarini J., De Clercq E., Harries T.Y., McGuigan C., Yarnold C.J.Fuentes:scopusMarked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection
ArticleAbstract: Lipophilic masked aryloxyaminoacylphosphoramidate derivatives of 2',3'- dideoxynucleoside (ddN) analPalabras claves:(Dideoxy)nucleoside analogues, AIDs, hiv, Masked aryloxyaminoacylphosphoramidate (dideoxy)nucleoside analogues, Reverse transcriptase, Visna virusAutores:Antonio Salgado, Balzarini J., Cahard D., De Clercq E., McGuigan C., Thormar H., Velázquez S., Wedgwood O., Yarnold C.J.Fuentes:scopusIdentification, occurrence and activity of quinazoline alkaloids in Peganum harmala
ArticleAbstract: Peganum harmala L. is a medicinal plant from the Mediterranean region and Asia currently used for rePalabras claves:Antioxidant activity, Deoxypeganine, Glycoside of peganine, Monoamine oxidase, Peganine (vasicine), Peganum harmala, β-CarbolinesAutores:Antonio Salgado, Arán V.J., Guillén H., Herraiz T.Fuentes:scopusMetabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety
ArticleAbstract: The metabolism of different phosphoramidate prodrugs of d4T-MP, in which the phosphate group is linkPalabras claves:Autores:Antonio Salgado, Baizarini J., Bidois L., Cahard D., De Clercq E., McGuigan C., Naesens L.Fuentes:scopusPhosphoramidate derivatives of d4T as inhibitors of HIV: The effect of amino acid variation
ArticleAbstract: Phosphoramidate derivatives of the nucleoside analogue, 2',3'-dideoxy-2',3'-didehydro thymidine (d4TPalabras claves:2',3'-Dideoxy-2',3'-didehydro thymidine, hiv, Nucleotide, Phosphoramidate, Pro-drugAutores:Antonio Salgado, Balzarini J., Bidois L., Cahard D., De Clercq E., McGuigan C., Naesens L., Tsang H.W., Turner K., Velázquez S.Fuentes:scopusPhosphoramidates as potent prodrugs of anti-HIV nucleotides: Studies in the amino region
ArticleAbstract: Novel phosphoramidate derivatives of the anti-HIV nucleoside analogues AZT and d4T have been preparePalabras claves:AZT, d4T, hiv, Nucleotide, ProdrugAutores:Antonio Salgado, Baizarinl J., Cahard D., De Clercq E., McGuigan C.Fuentes:scopus