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Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid In vivo bioactivity analysis of anti-inflammatory secondar metabolitesy
ArticleAbstract: Over the past decade, zebrafish (Danio rerio) have emerged as an attractive model for in vivo drug dPalabras claves:Farmacologia, LEUCOCITOS, PEZ CEBRAAutores:Alexander D. Crawford, Camila V. Esguerra, Dany Siverio Mota, Isabel María Wilches Arizábala, Liliana Vicet Muro, María Lorena Cordero-Maldonado, Peter A. M. Witte, deFuentes:rraaeIntegration of microfractionation, qNMR and zebrafish screening for the In vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products
ArticleAbstract: Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovPalabras claves:BIOENSAYO, PEZ CEBRAAutores:Alexander D. Crawford, Appolinary R. Kamuhabwa, Camila V. Esguerra, Dany Siverio Mota, Jan Maes, Jean-Luc Wolfender, Laurence Marcourt, Mainen J. Moshi, María Lorena Cordero-Maldonado, Nadine Bohni, Peter A. M. Witte, de, Sebastian MunckFuentes:rraae