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Molecular dynamics guided design of tocoflexol: A new radioprotectant tocotrienol with enhanced bioavailability
ArticleAbstract: Preclinical Research There is a pressing need to develop safe and effective radioprotector/radiomitiPalabras claves:Bioavailability, countermeasures, molecular dynamics, radiation protection, tocoflexol, tocotrienolAutores:Boerma M., Breen P.J., Cesar M. Compadre, Ghosh S., Hauer-Jensen M., Kiaei M., Singh A., Thakkar S., Varughese K.I., Zheng G.Fuentes:scopusSynthesis of (2R,8′S,3′E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol
ArticleAbstract: A group of side chain partially saturated tocotrienol analogues, namely tocoflexols, have been previPalabras claves:C–C coupling, Desulfonylation, Oxidative olefin cleavage, Tocodienol, tocotrienolAutores:Boerma M., Cesar M. Compadre, Crooks P.A., Gujarathi S., Hauer-Jensen M., Liu X., Shao L., Zhang X., Zheng G., Zhou D.Fuentes:scopus