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Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy
ArticleAbstract: Background: Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1Palabras claves:Autores:Avila-Chávez E., David B., Díaz L., Gamboa-Dominguez A., García-Becerra R., García-Quiroz J., Halhali A., Javier Camacho, Larrea F., Medina-Franco H., Ordaz-Rosado D., Rivas-Suárez M., Rodríguez P., Santos-Martínez N.Fuentes:scopusCalcitriol down-regulates human ether à go-go 1 potassium channel expression in cervical cancer cells
ArticleAbstract: Background/Aim: Human ether à-go-go-1 (EAG1) potassium channels are promising anticancer targets. CaPalabras claves:Calcitriol, Cervical Cancer, Eag1, PLACENTA, Potassium channels, Prostate cancer, vitamin DAutores:Avila-Chávez E., David B., Díaz L., Fernando L., García-Becerra R., Halhali A., Javier Camacho, Ordaz-Rosado D., Rodríguez-Rasgado J.A., Steinmeyer A., Zügel U.Fuentes:scopusCalcitriol inhibits Ether-à go-go potassium channel expression and cell proliferation in human breast cancer cells
ArticleAbstract: Antiproliferative actions of calcitriol have been shown to occur in many cell types; however, littlePalabras claves:Astemizole, Breast Cancer, K channels +, TEI-9647, VDR, vitamin DAutores:Arrecillas M., Avila-Chávez E., Bargallo E., David B., Díaz L., García-Becerra R., Halhali A., Javier Camacho, Larrea F., Morales A., Ordaz-Rosado D., Ortiz C.S.Fuentes:scopusCalcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: A potential new therapeutic approach
ArticleAbstract: Background: Approximately 30% of breast tumors do not express the estrogen receptor (ER) α, which isPalabras claves:Breast Cancer, Calcitriol, Estrogen receptor, Hormonal therapy, VDRAutores:Avila-Chávez E., David B., Díaz L., Esparza-López J., García-Becerra R., García-Quiroz J., Halhali A., Ibarra-Sánchez M., Javier Camacho, Larrea F., Medina-Franco H., Ordaz-Rosado D., Santos-Martínez N.Fuentes:scopusGenomic action of permanently charged tamoxifen derivatives via estrogen receptor-α
ArticleAbstract: Tamoxifen is a selective estrogen receptor modulator widely used in oncology and reproductive endocrPalabras claves:Breast Cancer, Estrogen receptor, Genomic action, Tamoxifen, Tamoxifen derivativesAutores:Bravo-Gómez M.E., Cooney A.J., García-Becerra R., Hernández-gallegos E., Javier Camacho, Larrea F., Morales-Ríos M.S., Ordaz-Rosado D., Pérez-Alvarez V., Rivera-Guevara C.Fuentes:scopusEstrogens and human papilloma virus oncogenes regulate human Ether-à-go-go-1 potassium channel expression
ArticleAbstract: Ether-à-go-go-1 (Eag1) potassium channels are potential tools for detection and therapy of numerousPalabras claves:Autores:Ahumada E., Alvarez-Rios E., Avila-Chávez E., Borja-Cacho E., Camacho-Arroyo I., Ceja-Ochoa I., David B., Díaz L., Escamilla J., Gamboa-Dominguez A., García-Becerra R., García-Latorre E., Garcia-Villa E., Gariglio P., Hernández-gallegos E., Javier Camacho, Larrea F., Morales A., Murbartián J., Ocadiz-Delgado R., Ordaz-Rosado D., Ortiz C.S., Restrepo-Angulo I., Rivera-Guevara C., Sánchez-Peña L.C., Saqui-Salces M., Uribe-Ramírez M., Vera E., Vizcaya-Ruiz A.D.Fuentes:scopusIn vivo dual targeting of the oncogenic ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors
ArticleAbstract: Background: The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necesPalabras claves:Breast Cancer, Eag1, Ki-67, Targeted therapy, vitamin D, Vitamin D receptorAutores:Avila-Chávez E., David B., Díaz L., Esparza-López J., Gamboa-Dominguez A., García-Becerra R., García-Quiroz J., Halhali A., Ibarra-Sánchez M., Javier Camacho, Larrea F., Ordaz-Rosado D., Santos-Martínez N., Villanueva O.Fuentes:scopus