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Biochimica et Biophysica Acta - Biomembranes(4)
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Anticancer Agent Edelfosine Exhibits a High Affinity for Cholesterol and Disorganizes Liquid-Ordered Membrane Structures
ArticleAbstract: Edelfosine is an anticancer drug with an asymmetric structure because, being a derivative of glyceroPalabras claves:Autores:Alessio Ausili, Corbalán-García S., De Godos A., Gómez-Murcia V., Gómez‐Fernández J.C., Martínez-Valera P., Teruel J.A., Torrecillas A.Fuentes:googlescopusCapsaicin Fluidifies the Membrane and Localizes Itself near the Lipid-Water Interface
ArticleAbstract: Capsaicin is the chemical responsible for making some peppers spicy hot, but additionally it is usedPalabras claves:1 H NOESY MAS NMR, 2 H NMR, Capsaicin, dsc, membranes, SAXD, WAXDAutores:A Ausili, Alessio Ausili, Corbalán-García S., De Godos A., Fernández-Martínez A., Gómez‐Fernández J.C., Schneider M., Torrecillas A.Fuentes:googlerraaescopusCurcumin disorders 1,2-dipalmitoyl-sn-glycero-3-phosphocholine membranes and favors the formation of nonlamellar structures by 1,2-dielaidoyl-sn-glycero- 3-phosphoethanolamine
ArticleAbstract: Curcumin is a polyphenol present in turmeric, a spice widely used in Asian traditional medicine andPalabras claves:Autores:Alessio Ausili, Aranda F.J., Corbalán-García S., Godos A.D., Gómez‐Fernández J.C., Pérez-Lara A., Torrecillas A.Fuentes:googlescopusEdelfosine is incorporated into rafts and alters their organization
ArticleAbstract: The effect of edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3- phosphocholine or ET-18-OCH3) on mPalabras claves:Autores:Alessio Ausili, Aranda F.J., Corbalán-García S., De Godos A., Gajate C., Gómez‐Fernández J.C., Mollinedo F., Torrecillas A.Fuentes:googlescopusInteraction of Vitamin K<inf>1</inf> and Vitamin K<inf>2</inf> with Dimyristoylphosphatidylcholine and Their Location in the Membrane
ArticleAbstract: Vitamin K1 and vitamin K2 play very important biological roles as members of chains of electron tranPalabras claves:Autores:Alessio Ausili, Clemente J., Corbalán-García S., De Godos A., Ghmez-Fernández J.C., Pons-Belda Ó.D., Teruel J.A., Torrecillas A.Fuentes:googlescopusInteraction of the C-terminal domain of Bcl-2 family proteins with model membranes
ArticleAbstract: Bcl-2 family proteins are involved in the cell homeostasis by regulating programmed cell death. SomePalabras claves:apoptosis, Bak, BAX, BCL-2, Fluorescence, Protein-lipid interactionAutores:Alessio Ausili, Corbalán-García S., Gómez‐Fernández J.C., Martínez-Senac M., Torrecillas A.Fuentes:googlescopusThe binding of different model membranes with PKCε C2 domain is not dependent on membrane curvature but affects the sequence of events during unfolding
ArticleAbstract: The C2 domain of novel protein kinases C (nPKC) binds to membranes in a Ca2+-independent way contribPalabras claves:Infrared spectroscopy, Membrane curvature, Model membranes, Protein kinase Cε, Protein unfoldingAutores:Alessio Ausili, Corbalán-García S., Gómez‐Fernández J.C.Fuentes:googlescopusThe interaction of the Bax C-terminal domain with membranes is influenced by the presence of negatively charged phospholipids
ArticleAbstract: The C-terminal domain of the pro-apoptotic protein Bax (Bax-C) is supposed to act as a membrane anchPalabras claves:13 C-NMR, 31 P-NMR, apoptosis, BAX, MAS-NMR, Protein-lipid interactionAutores:Alessio Ausili, Corbalán-García S., De Godos A., Gómez‐Fernández J.C., Torrecillas A.Fuentes:googlescopusThe interaction of the Bax C-terminal domain with negatively charged lipids modifies the secondary structure and changes its way of insertion into membranes
ArticleAbstract: Fourier transform infrared spectroscopy (FTIR) was used to study the secondary structure of peptidesPalabras claves:apoptosis, ATR-FTIR, BAX, Infrared spectroscopyAutores:Alessio Ausili, Corbalán-García S., Gómez‐Fernández J.C., Martínez-Senac M., Torrecillas A.Fuentes:googlescopusThe membrane binding kinetics of full-length PKCα is determined by membrane lipid composition
ArticleAbstract: Protein kinase Cα (PKCα) is activated by its translocation to the membrane. Activity assays show thePalabras claves:PIP 2, PKCα, Rapid kinetics, stopped-flowAutores:Alessio Ausili, Corbalán-García S., Egea-Jiménez A., Gómez‐Fernández J.C., Pérez-Lara A.Fuentes:googlescopus