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scopus(5)
CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans
ArticleAbstract: CYP2D6 genotype and debrisoquine metabolic ratio (MR) were analyzed in 133 Nicaraguan Mestizos (NMs)Palabras claves:Cubans, CYP2D6, debrisoquine hydroxylation, Latinos, Nicaraguans, PhenotypeAutores:Adrián LLerena, Alvárez M., Calzadilla L.R., Dorado P., González I., Penãs-Lledó E.M., Pérez B., Ramirez R.Fuentes:scopusCYP2D6-1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers
ArticleAbstract: Background & aim: The CYP2D6-1584C>G polymorphism (rs1080985) has been identified as a major factorPalabras claves:1584C>G, CYP2D6, debrisoquine, Healthy volunteers, ultrarapid metabolismAutores:Adrián LLerena, Alvárez M., Calzadilla L.R., Dorado P., González I., Naranjo M.E.G., Penãs-Lledó E.M., Pérez B., Ramirez R.Fuentes:scopusMolecular heterogeneity at the CYP2D gene locus in Nicaraguans: Impact of gene-flow from Europe
ArticleAbstract:Palabras claves:CYP2D, Cytochrome p450, Gene-flow, Hispanics, NicaraguansAutores:Adrián LLerena, Agúndez J.A.G., Benitez Rodriguez J., Hernandez M., Ramirez R.Fuentes:scopusInfluence of genetic admixture on polymorphisms of drug-metabolizing enzymes: Analyses of mutations on NAT2 and CYP2E1 genes in a mixed Hispanic population
ArticleAbstract: Objectives and study design: The genetic basis of two polymorphisms of drug- and carcinogen-metaboliPalabras claves:Autores:Adrián LLerena, Agúndez J.A.G., Benitez Rodriguez J., Hernandez M., Martínez C., Olivera M., Ramirez R.Fuentes:scopusPharmacogenetics in Central American healthy volunteers: Interethnic variability
ReviewAbstract: Ethnicity is one of the major factors involved in interindividual variability to drug response. ThisPalabras claves:Admixed, Afro-Caribbean, Amerindian, Biomarkers, Central America, CYP1A2, CYP2C19, CYP2D6, CYP2E1, G6PD, HLA, LDLR, MDR1, NAT2, pharmacogenetics, TP53Autores:Adrián LLerena, Barrantes R., Céspedes-Garro C., Humberto Fariñas, Naranjo M.E.G., Ramirez R., Serrano V.Fuentes:scopus