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CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans
ArticleAbstract: CYP2D6 genotype and debrisoquine metabolic ratio (MR) were analyzed in 133 Nicaraguan Mestizos (NMs)Palabras claves:Cubans, CYP2D6, debrisoquine hydroxylation, Latinos, Nicaraguans, PhenotypeAutores:Adrián LLerena, Alvárez M., Calzadilla L.R., Dorado P., González I., Penãs-Lledó E.M., Pérez B., Ramirez R.Fuentes:scopusCYP2D6-1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers
ArticleAbstract: Background & aim: The CYP2D6-1584C>G polymorphism (rs1080985) has been identified as a major factorPalabras claves:1584C>G, CYP2D6, debrisoquine, Healthy volunteers, ultrarapid metabolismAutores:Adrián LLerena, Alvárez M., Calzadilla L.R., Dorado P., González I., Naranjo M.E.G., Penãs-Lledó E.M., Pérez B., Ramirez R.Fuentes:scopusMolecular heterogeneity at the CYP2D gene locus in Nicaraguans: Impact of gene-flow from Europe
ArticleAbstract:Palabras claves:CYP2D, Cytochrome p450, Gene-flow, Hispanics, NicaraguansAutores:Adrián LLerena, Agúndez J.A.G., Benitez Rodriguez J., Hernandez M., Ramirez R.Fuentes:scopusInfluence of genetic admixture on polymorphisms of drug-metabolizing enzymes: Analyses of mutations on NAT2 and CYP2E1 genes in a mixed Hispanic population
ArticleAbstract: Objectives and study design: The genetic basis of two polymorphisms of drug- and carcinogen-metaboliPalabras claves:Autores:Adrián LLerena, Agúndez J.A.G., Benitez Rodriguez J., Hernandez M., Martínez C., Olivera M., Ramirez R.Fuentes:scopusPharmacogenetic research activity in Central America and the Caribbean: A systematic review
ReviewAbstract: Aim: The present review was aimed at analyzing the pharmacogenetic scientific activity in Central AmPalabras claves:Biomarkers, Caribbean Region, Central America, pharmacogenetics, PharmacogenomicsAutores:Adrián LLerena, Campos M.D.L.A., Céspedes-Garro C., Duconge J., Humberto Fariñas, Montané-Jaime L.K., Naranjo M.E.G., Penãs-Lledó E.M., Ramirez R., Roblejo H., Rodrigues-Soares F., Serrano V., Villagrán C.I.Fuentes:scopusPharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America
Conference ObjectAbstract: Congress of Pharmacogenetics and Personalized Medicine. Ethnicity, clinical implementation and regulPalabras claves:clinical trials, Latin American populations, metabolic genotypes, Metabolic phenotypes, native populations, pharmacogenetics, pharmacovigilanceAutores:Adrián LLerena, Altamirano C., Céspedes-Garro C., Enrique Terán, Francisco J.López Hernández, Galaviz-Hernandez C., Humberto Fariñas, Jung-Cook H., López-López M., MARTHA FORS, Martha M. Fors-López, Moya G.E., Ramirez R., Remírez D., Sosa-Macías M.G., Tarazona-Santos E.M., William F. WatersFuentes:googlescopusPharmacogenetics in Central American healthy volunteers: Interethnic variability
ReviewAbstract: Ethnicity is one of the major factors involved in interindividual variability to drug response. ThisPalabras claves:Admixed, Afro-Caribbean, Amerindian, Biomarkers, Central America, CYP1A2, CYP2C19, CYP2D6, CYP2E1, G6PD, HLA, LDLR, MDR1, NAT2, pharmacogenetics, TP53Autores:Adrián LLerena, Barrantes R., Céspedes-Garro C., Humberto Fariñas, Naranjo M.E.G., Ramirez R., Serrano V.Fuentes:scopusPopulation pharmacogenetics of Ibero-Latinoamerican populations (MESTIFAR 2014)
Conference ObjectAbstract: MESTIFAR 2014 28-30 November 2014, Panama City, Panama The CEIBA consortium was created within the IPalabras claves:Cytochrome p450, drug metabolism, genome-wide analyses, Ibero-Americans populations, Metabolic phenotypes, next-generation sequencing, pharmacogenetics, Population geneticsAutores:Acosta H., Adrián LLerena, Céspedes-Garro C., Enrique Terán, Galaviz-Hernandez C., Moya G.E., Penãs-Lledó E.M., Ramirez R., Sosa-Macías M.G., Tarazona-Santos E.M.Fuentes:googlescopus