Mostrando 10 resultados de: 10
Filtros aplicados
Publisher
British Journal of Clinical Pharmacology(2)
Therapeutic Drug Monitoring(2)
Acta Psychiatrica Scandinavica(1)
Clinical neuropharmacology(1)
European Journal of Clinical Pharmacology(1)
Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.
ArticleAbstract: In a previous study we showed that the disposition of clozapine after a single oral dose is unrelatePalabras claves:Autores:Adrián LLerena, Alm C., Benitez Rodriguez J., Bertilsson L., Bondesson U., Carrillo J., Dahl M.L., Lindstrom L., Ramos S., Rodriguez de la Rubia I.Fuentes:scopusFrequency of S-mephenytoin hydroxylation deficiency in 373 spanish subjects compared to other Caucasian populations
ArticleAbstract: We have investigated the prevalence of poor metabolisers (PM) of S-mephenytoin in 373 unrelated, heaPalabras claves:caucasian, drug metabolism, Mephenytoin, pharmacogenetics, Phenotype, polymorphismAutores:Adrián LLerena, Benitez Rodriguez J., Bertilsson L., Carrillo J.A., Reviriego J., Valdivielso M.J.Fuentes:scopusGenetic factors in the metabolism of haloperidol.
ArticleAbstract:Palabras claves:Autores:Adrián LLerena, Bertilsson L., Dahl M.L., Ekqvist B.Fuentes:scopusDisposition of clozapine in man: lack of association with debrisoquine and S‐mephenytoin hydroxylation polymorphisms.
ArticleAbstract: A large interindividual variability has previously been demonstrated in the bioavailability, steady‐Palabras claves:Autores:Adrián LLerena, Bertilsson L., Bondesson U., Dahl M.L., Lindstrom L.Fuentes:scopusDisposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation.
ReviewAbstract:Palabras claves:Autores:Adrián LLerena, Bertilsson L., Dahl M.L., Ekqvist B.Fuentes:scopusHaloperidol disposition is dependent on debrisoquine hydroxylation phenotype
ArticleAbstract: To investigate the importance of genetic factors for the regulation of haloperidol metabolism, we stPalabras claves:debrisoquine, Haloperidol, humans, pharmacogeneticsAutores:Adrián LLerena, Alm C., Bertilsson L., Dahl M.L., Ekqvist B.Fuentes:scopusHaloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: Increased plasma levels of the reduced metabolite in poor metabolizers
ArticleAbstract: We have previously shown that the disposition of haloperidol is decreased in poor (PM) compared to ePalabras claves:debrisoquine, humans, pharmacogenetics, Reduced haloperidolAutores:Adrián LLerena, Bertilsson L., Dahl M.L., Ekqvist B.Fuentes:scopusRelationship between personality and debrisoquine hydroxylation capacity: Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6
ArticleAbstract: We administered the Karolinska Scales of Personality to 225 healthy subjects in Spain selected fromPalabras claves:debrisoquine, personality, pharmacogeneticsAutores:Adrián LLerena, Benitez Rodriguez J., Bertilsson L., Cobaleda J., Edman G., Schalling D.Fuentes:scopusReproducibility over Time of Mephenytoin and Debrisoquine Hydroxylation Phenotypes
ArticleAbstract: Mephenytoin and debrisoquine hydroxylation phenotypes were determined twice in 15 Spanish healthy voPalabras claves:Autores:Adrián LLerena, Benitez Rodriguez J., Bertilsson L., Valdivielso M.J.Fuentes:scopusThe psychostimulant khat (Catha edulis) inhibits CYP2D6 enzyme activity in humans
ArticleAbstract: The use of khat (Catha edulis) while on medication may alter treatment outcome. In particular, the iPalabras claves:cathine, cathinone, CYP2D6, dextromethorphan, drug interaction, khatAutores:Adrián LLerena, Aklillu E., Beck O., Bedada W., Bertilsson L., de Andrés F., Engidawork E., Pohanka A.Fuentes:scopus