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METTL1-mediated m<sup>7</sup>G modification of Arg-TCT tRNA drives oncogenic transformation
ArticleAbstract: The emerging “epitranscriptomics” field is providing insights into the biological and pathological rPalabras claves:Arg-TCT, Cáncer, m G 7, METTL1, N -methylguanosine 7, oncogene, translation, tRNAAutores:Ali R., Aspris D., Bernardes G.J.L., Bradley A., De Braekeleer E., Esteban A. Orellana, Fischer E.S., Garyfallos D.A., Gregory R.I., Gu M., Gutierrez A., Lim J., Liu Q., Mikutis S., Pirouz M., Sendinc E., Slack F.J., Tzelepis K., Vassiliou G.S., Yankova E., Zhang W.Fuentes:scopusMETTL4 is an snRNA m<sup>6</sup>Am methyltransferase that regulates RNA splicing
OtherAbstract:Palabras claves:Autores:Chen H., Esteban A. Orellana, Gregory R.I., Gu L., Guo J., Liu Q., Shen Z., Shi Y., Wang L., Wang Y., Wu H., Xing Y.Fuentes:scopustRNA dysregulation and disease
ReviewAbstract: tRNAs are key adaptor molecules that decipher the genetic code during translation of mRNAs in proteiPalabras claves:Autores:Esteban A. Orellana, Gregory R.I., Siegal E.Fuentes:scopusStructural basis of regulated m<sup>7</sup>G tRNA modification by METTL1–WDR4
ArticleAbstract: Chemical modifications of RNA have key roles in many biological processes1–3. N7-methylguanosine (m7Palabras claves:Autores:Arthanari H., Esteban A. Orellana, Fischer E.S., Fontana P., Gregory R.I., Hahn Q., Hunkeler M., Li J., Nowak R.P., Roy Burman S.S., Viennet T., Wang L., Wu H., Yue H.Fuentes:scopusSynthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
ArticleAbstract: Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical prPalabras claves:acute leukemia, asparaginase, asparagine, Drug resistance, FBXW7, GSK3, proteasomal degradation, protein ubiquitination, synthetic lethality, Wnt signalingAutores:Bauer D.E., Degar J., Esteban A. Orellana, Gregory R.I., Gutierrez A., Hinze L., Karim S., McGuckin C., Neuberg D.S., Pfirrmann M., Sacher J., Stanulla M., Stegmaier K., Stevenson K.E., Vinjamur D., Wagner F.F.Fuentes:scopus