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Isolation, molecular cloning and functional characterization of a novel β-toxin from the Venezuelan scorpion, Tityus zulianus
ArticleAbstract: Sting in children by Tityus zulianus scorpions (western Venezuela) often produces cardiorespiratoryPalabras claves:Beta-scorpion toxin, ESI/MS, electrospray ionization mass spectrometry, K , voltage-gated potassium channel V, Na , voltage-gated sodium channel V, Receptor site-4, Sodium channel activation, Tityus, Tityus zulianusAutores:Adolfo Borges, Alfonzo M.J., García C.C., Heinemann S.H., Leipold E., Winand N.J.Fuentes:scopusScorpion β-toxin interference with Na <inf>v</inf> channel voltage sensor gives rise to excitatory and depressant modes
ArticleAbstract: Scorpion β toxins, peptides of ~70 residues, specifically target voltage-gated sodium (Na V) channelPalabras claves:Autores:Adolfo Borges, Heinemann S.H., Leipold E.Fuentes:scopusμo-Conotoxins inhibit Na<inf>v</inf> channels by interfering with their voltage sensors in domain-2
ArticleAbstract: The μO-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-sPalabras claves:Conotoxin, Gating, Pain, Patch clamp, Sodium channel, Voltage sensorAutores:Adolfo Borges, De Bie H., Heinemann S.H., Leipold E., Olivera B., Terlau H., Zorn S.Fuentes:scopusSubtype specificity of scorpion β-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3
ArticleAbstract: Voltage-gated sodium (Nav) channels are modulated by a variety of specific neurotoxins. Scorpion β-tPalabras claves:Autores:Adolfo Borges, Hansel A., Heinemann S.H., Leipold E.Fuentes:scopus