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scopus(5)
15-Deoxy-Δ<sup>12,14</sup>-prostaglandin-J<inf>2</inf> reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation
ArticleAbstract: Hypoxia-inducible factor-1α (HIF-1α) protein is degraded under normoxia by its association to von HiPalabras claves:15-Deoxy-Δ -prostaglandin- J 12,14 2, Calpain, Heat shock protein-90, Hypoxia inducible factor, Lysosome, Proximal tubular cellsAutores:Aragonés J., Arenas M.I., Bienes R., Calzada M.J., Garcia-Bermejo M.L., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G.Fuentes:scopusInadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells
ArticleAbstract: The von Hippel-Lindau (VHL) tumor suppressor gene regulates extracellular matrix deposition. In VHLPalabras claves:Autores:Calzada M.J., Castellanos M.C., Del Cerro M.H., Esteban M.A., Feijóo-Cuaresma M., García‐Pardo A., Manuel Ortiz de Landázuri, Maqueda A., Méndez F., Naranjo-Suárez S., Vazquez S.N.Fuentes:scopusTargeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: The METOXIA consortium
ReviewAbstract: The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of which treaPalabras claves:Bioreductive compounds, cancer-treatment resistance, carbonic anhydrase inhibitors, dual-activity compounds, non-invasive oxygen detection, targets for new treatmentAutores:Ahmed A., Alsner J., Ashcroft M., Buffa F.M., Busk M., Calzada M.J., Cao Y., Chiche J., Cojocari D., Dubois L., Ebbesen P., Flamm H., Flatmark K., Gieling R.G., Görlach A., Haider S., Harris A.L., Jobst G., Kieninger J., Koritzinsky M., Kunkler I.H., Lambin P., Langdon S.P., Lyng H., Manuel Ortiz de Landázuri, Marchiq I., Mazure N., Meehan J., Moser I., Mujcic H., Overgaard J., Parks S., Pastorekova S., Peso L.D., Pettersen E.O., Pouyssegur J., Ree A.H., Rouschop K.M., Scozzafava A., Singleton D.C., Supuran C.T., Toustrup K., Urban G., Ward C., Weltin A., Williams K.J., Wouters B.G.Fuentes:scopusVon Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms
ArticleAbstract: Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is responsible for the developmentPalabras claves:Autores:Calzada M.J., Castellanos M.C., Esteban M.A., Feijóo-Cuaresma M., Manuel Ortiz de Landázuri, Méndez F., Naranjo-Suárez S., Ohh M., Temes E., Yáñez-Mó M.Fuentes:scopusMacrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-γ production through the HIF-1α transcription factor
ArticleAbstract: Low oxygen tension areas are found in inflamed or diseased tissues where hypoxic cells induce survivPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Calzada M.J., Elorza A., Manuel Ortiz de Landázuri, Martín-Cofreces N.B., Martin-Puig S., Miro M., Olazabal I.M., Sánchez‐Madrid F.Fuentes:scopus