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Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
ArticleAbstract: The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat toPalabras claves:acetohydroxyacid synthase, Antifungal drug, Candida Albicans, Crystal structure, HerbicideAutores:Agnew-Francis K., Chua S.M.H., Fraser J.A., Guddat L.W., Lee Y.T., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Nouwens A., Wang J.G., Williams C.M.Fuentes:googlescopusHigh Resolution Crystal Structures of the Acetohydroxyacid Synthase-Pyruvate Complex Provide New Insights into Its Catalytic Mechanism
ArticleAbstract: Acetohydroxyacid synthase (AHAS) is the first enzyme in the biosynthesis pathway of the branched-chaPalabras claves:acetohydroxyacid synthase, FAD, O 2, pyruvate, RedoxAutores:Fraser J.A., Guddat L.W., Harmer J., Lonhienne T., Mario Daniel García, Noble C., Williams C.M.Fuentes:scopusTriazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads
ArticleAbstract: Aspergillus fumigatus is a fungal pathogen whose effects can be debilitating and potentially fatal iPalabras claves:Autores:Fraser J.A., Guddat L.W., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Schenk G.Fuentes:googlescopusStructures of fungal and plant acetohydroxyacid synthases
ArticleAbstract: Acetohydroxyacid synthase (AHAS), also known as acetolactate synthase, is a flavin adenine dinucleotPalabras claves:Autores:Brillault L., Croll T., Fraser J.A., Gao Y., Guddat L.W., Landsberg M.J., Lonhienne T., Low Y.S., Mario Daniel García, McGeary R.P., Rao Z., Schenk G., Wang Q., West N.P., Williams C.M.Fuentes:scopusThe 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements
ArticleAbstract: Acetohydroxyacid synthase (AHAS) catalyzes the first step of branched-chain amino acid biosynthesis,Palabras claves:Autores:Fraser J.A., Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Williams C.M.Fuentes:googlescopus