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Article(3)
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Antioxidants(1)
Current Topics in Medicinal Chemistry(1)
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scopus(3)
Fri-1 is an anti-cancer isoquinolinequinone that inhibits the mitochondrial bioenergetics and blocks metabolic shifts by redox disruption in breast cancer cells
ArticleAbstract: Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferatPalabras claves:2-oxoglutarate dehydrogenase (OGDH), AMP-activated kinase (AMPK) signaling, CPI-613, Devimistat, Mitocans, Mitochondria, Tricarboxylic acid (TCA) cycleAutores:Araya-Maturana R., Córdova-Delgado M., Fuentes-Retamal S., Guzmán-Rivera D., López-Torres C., Oney O. Ramírez-Rodríguez, Palominos C., Urra F.A.Fuentes:scopusMitochondria: A promising target for anticancer alkaloids
ArticleAbstract: A great number of alkaloids exhibit high potential in cancer research. Some of them are anticancer dPalabras claves:alkaloids, apoptosis, Cancer cells, DELIVERY, Endoplasmic reticulum, Mitochondria, targetingAutores:Araya-Maturana R., Córdova-Delgado M., Ferreira J., Oney O. Ramírez-Rodríguez, Pessoa-Mahana H., Urra F.A., Weiss-López B.Fuentes:scopusSmall structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation
ArticleAbstract: Mitochondria participate in several distinctiveness of cancer cell, being a promising target for thePalabras claves:Anti-cancer agents, Complex I, Hydroquinones, Oxidative phosphorylation, UncouplersAutores:Acevedo-Arévalo L., Andrea Orellana Manzano, Araya-Maturana R., Córdova-Delgado M., Ferreira J., González-Vivanco J.M., Lapier M., Martínez-Cifuentes M., Millas-Vargas J.P., Oney O. Ramírez-Rodríguez, Pavani M., Pessoa-Mahana H., Urra F.A., Weiss-López B.Fuentes:scopus