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Antioxidants(1)
Current Topics in Medicinal Chemistry(1)
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Fri-1 is an anti-cancer isoquinolinequinone that inhibits the mitochondrial bioenergetics and blocks metabolic shifts by redox disruption in breast cancer cells
ArticleAbstract: Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferatPalabras claves:2-oxoglutarate dehydrogenase (OGDH), AMP-activated kinase (AMPK) signaling, CPI-613, Devimistat, Mitocans, Mitochondria, Tricarboxylic acid (TCA) cycleAutores:Araya-Maturana R., Córdova-Delgado M., Fuentes-Retamal S., Guzmán-Rivera D., López-Torres C., Oney O. Ramírez-Rodríguez, Palominos C., Urra F.A.Fuentes:scopusFR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway
ArticleAbstract: Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cePalabras claves:Autores:Ahumada-Castro U., Araya-Maturana R., Bustos G., Cárdenas C., Córdova-Delgado M., Cruz P., Ferreira J., Millas-Vargas J.P., Morales D., Muñoz F., Oney O. Ramírez-Rodríguez, Pavani M., Peña-Ahumada B., Pessoa-Mahana H., Pulgar R., Ramírez M.P., Retamal E., Rios M., Silva-Pavez E., Urra F.A., Varela D.Fuentes:scopusFirst reports of envenoming by South American water snakes Helicops angulatus and Hydrops triangularis from Bolivian Amazon: A one-year prospective study of non-front-fanged colubroid snakebites
ArticleAbstract: Although snakebite incidence is underestimated in Bolivia, the Amazon region presents the highest inPalabras claves:Bolivian Amazon, Human-snake conflict, Mild coagulopathy, Non-front-fanged colubroid, SnakebitesAutores:Beatriz Nieto-Ariza, Chippaux J.P., León R., Rocabado J.A., Urra F.A., Villca-Corani H.Fuentes:scopusMitochondria: A promising target for anticancer alkaloids
ArticleAbstract: A great number of alkaloids exhibit high potential in cancer research. Some of them are anticancer dPalabras claves:alkaloids, apoptosis, Cancer cells, DELIVERY, Endoplasmic reticulum, Mitochondria, targetingAutores:Araya-Maturana R., Córdova-Delgado M., Ferreira J., Oney O. Ramírez-Rodríguez, Pessoa-Mahana H., Urra F.A., Weiss-López B.Fuentes:scopusSmall structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation
ArticleAbstract: Mitochondria participate in several distinctiveness of cancer cell, being a promising target for thePalabras claves:Anti-cancer agents, Complex I, Hydroquinones, Oxidative phosphorylation, UncouplersAutores:Acevedo-Arévalo L., Andrea Orellana Manzano, Araya-Maturana R., Córdova-Delgado M., Ferreira J., González-Vivanco J.M., Lapier M., Martínez-Cifuentes M., Millas-Vargas J.P., Oney O. Ramírez-Rodríguez, Pavani M., Pessoa-Mahana H., Urra F.A., Weiss-López B.Fuentes:scopus