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N-Butylpyrrolidinone for Solid-Phase Peptide Synthesis is Environmentally Friendlier and Synthetically Better than DMF
ArticleAbstract: Solid-phase peptide synthesis (SPPS) is the method of choice for the preparation of peptides in bothPalabras claves:aspartimide formation, Green solvent, N-butylpyrrolidinone, Racemization, Solid-phase peptide synthesisAutores:Alberício F., Alhassan M., B. G. De la Torre, Kumar A., Lopez J.Fuentes:scopusRefractive Index: The Ultimate Tool for Real-Time Monitoring of Solid-Phase Peptide Synthesis. Greening the Process
ArticleAbstract: Peptides are the basis of many drugs currently on the market and of more in advanced studies. Most pPalabras claves:Fmoc removal, PAT, peptide coupling, process analytical tool, SPPSAutores:Alberício F., B. G. De la Torre, Lopez J., Ramkisson S.Fuentes:scopusRevisiting no<inf>2</inf> as protecting group of arginine in solid-phase peptide synthesis
ArticleAbstract: The protection of side-chain arginine in solid-phase peptide synthesis requires attention since currPalabras claves:MICROWAVE, NBP, Orthogonal protection, Protecting group, Side-reaction, Solid-phase peptide synthesis, Sonochemistry, Ultrasounds, δ-lactam formationAutores:Alberício F., Alhassan M., B. G. De la Torre, Kumar A., Lopez J.Fuentes:scopusSuccessful development of a method for the incorporation of Fmoc-Arg(Pbf)-OH in solid-phase peptide synthesis using: N -butylpyrrolidinone (NBP) as solvent
ArticleAbstract: NBP has proved an excellent alternative solvent to the hazardous DMF for SPPS. Here we studied the iPalabras claves:Autores:Alberício F., Alhassan M., B. G. De la Torre, Bucher C., Kumar A., Lopez J.Fuentes:scopus