Mostrando 2 resultados de: 2
Anti-inflammatory activity and cheminformatics analysis of new potent 2-substituted 1-methyl-5-nitroindazolinones
ArticleAbstract: After the identification of the anti-inflammatory properties of VA5-13l (2-benzyl-1- methyl-5-nitroiPalabras claves:Anti-inflammatory compound, Nitroindazolinones, SARANEA software, Structure-activity relationship, TPA-induced mouse ear edema, zebrafishAutores:Andújar I., Arán V.J., Crawford A.D., De Witte P.A.M., Díaz-Mendoza C., Giner R.M., Manjarrez G., María Lorena Cordero-Maldonado, Pérez-Jiménez F., Siverio-Mota D., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:scopusDiscovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopus