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Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8
ArticleAbstract: The senescence-accelerated strains of mice (SAMP) are well-characterized animal models of senescencePalabras claves:Calpain, Catalase, Neurodegeneration, Oxidative Stress, Senescence, TauAutores:Antoni Camins, Canudas A.M., Gutiérrez-Cuesta J., Mallol J., Mulero M., Pallás M., Romeu M., Sureda F.X.Fuentes:scopusCyclosporin A enhances colchicine-induced apoptosis in rat cerebellar granule neurons
ArticleAbstract: 1 Cyclosporin A (CsA, 1-50 μM), an immunosuppressive drug with known neurotoxic effects, did not decPalabras claves:CDK5, colchicine, Cyclosporin A, flavopiridol, Neurotoxicity, RoscovitineAutores:Antoni Camins, Canudas A.M., Jiménez A., Jordá E.G., Pallás M., Rimbau V., Sureda F.X., Verdaguer E.Fuentes:scopusAmyloid and tau pathology of familial Alzheimer’s disease APP/PS1 mouse model in a senescence phenotype background (SAMP8)
ArticleAbstract: The amyloid precursor protein/presenilin 1 (APP/PS1) mouse model of Alzheimer’s disease (AD) has proPalabras claves:aging, cognitive impairment, Familial Alzheimer’s disease (fAD), Tau hyperphosphorylation, β-AmyloidAutores:Andrés-Benito P., Antoni Camins, Canudas A.M., Del Valle J., Ferrer I., Griñan-Ferré C., Pallás M., Porquet D.Fuentes:scopusNeuroprotective effects of (±)-huprine Y on in vitro and in vivo models of excitoxicity damage
ArticleAbstract: We have investigated the neuroprotective effects of (±)-huprine Y on excitotoxic lesions in rat cerePalabras claves:3-nitropropionic acid, Cerebellar granule cells, glutamate, Huprines, neuroprotectionAutores:Antoni Camins, Camps P., Canudas A.M., Jiménez A., Muñoz-Torrero D., Pallás M., Pubill D., Sureda F.X., Verdaguer E.Fuentes:scopusIncreased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
ArticleAbstract: SAMP8 mice show several indicative characteristics of accelerated aging and have been used to studyPalabras claves:blood-brain barrier, Confocal microscopy, hippocampus, IgG quantification, Immunohistochemistry, mouse, SAMP8, SenescenceAutores:Antoni Camins, Canudas A.M., Casadesús G., Del Valle J., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusInhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons
ArticleAbstract: Serum and potassium (S/K) deprivation is a well-known apoptotic model in cerebellar granule neuronsPalabras claves:apoptosis, Cdk, cell cycle, flavopiridol, GSK-3β, MEF2Autores:Alvira D., Antoni Camins, Canudas A.M., Folch J., Jiménez A., Jordá E.G., Pallás M., Rimbau V., Verdaguer E.Fuentes:scopusLong-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues
ArticleAbstract: The protein deacetylase, sirtuin 1, is suggested as a master regulator of exercise-induced beneficiaPalabras claves:AMPK, heart, Liver, Mitochondrial biogenesis, Muscle, Oxidative Stress, PGC-1α, Sirtuin 1, TreadmillAutores:Antoni Camins, Bayod S., Canudas A.M., Coto-Montes A., de Luxán-Delgado B., Del Valle J., Escorihuela R.M., Lalanza J.F., Pallás M., Sanchez-Roige S.Fuentes:scopusKainic acid-induced apoptosis in cerebellar granule neurons: An attempt at cell cycle re-entry
ArticleAbstract: This study was undertaken to investigate whether kainic acid (KA) may regulate the expression of sevPalabras claves:apoptosis, Cdk, cell cycle, Cyclines, E2F-1, Kainic acidAutores:Antoni Camins, Canudas A.M., Domínguez E., Escubedo E., García-Jordà E., Jiménez A., Pallás M., Pubill D., Verdaguer E.Fuentes:scopusWnt pathway regulation by long-term moderate exercise in rat hippocampus
ArticleAbstract: An active lifestyle involving regular exercise reduces the deleterious effects of the aging process.Palabras claves:DKK-1, Environmental enrichment, hippocampus, Long-term moderate exercise, Wnt, β-cateninAutores:Antoni Camins, Bayod S., Canudas A.M., Escorihuela R.M., Lalanza J.F., Mennella I., Pallás M., Sanchez-Roige S.Fuentes:scopusResveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway
ArticleAbstract: Metabolic stress induced by high-fat (HF) diet leads to cognitive dysfunction and aging, but the phyPalabras claves:aging, Behavior, COGNITION, Diabetes metabolic stress, Fission, Fusion, Learning, Mitochondria, Mitochondrial dynamics, Neurodegeneration, Resveratrol, β-cateninAutores:Antoni Camins, Canudas A.M., Griñan-Ferré C., Pallás M., Palomera-ávalos V., Puigoriol-Ilamola D., Sanfeliu C.Fuentes:scopus