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New chromene scaffolds for adenosine A<inf>2A</inf> receptors: Synthesis, pharmacology and structure-activity relationships
ArticleAbstract: In silico screening of a collection of 1584 academic compounds identified a small molecule hit for tPalabras claves:Adenosine receptors, Chromene scaffolds, G protein-coupled receptors, Knoevenagel condensation, Structure-activity relationshipAutores:Brea J., Castro M., Costa M., Filipe Miguel Areias, Gregori-Puigjané E., Loza M.I., Mestres J., Proença M.F.Fuentes:googlescopusIdentification of novel scaffolds from an original chemical library as potential antipsychotics
Conference ObjectAbstract: The ligand-based virtual screening of an original chemical library, using atypical antipsychotics asPalabras claves:5-HT 2A, Antipsychotic, drug design, Purine, serotonin receptors, Virtual ScreeningAutores:Brea J., Cadavid M.I., Carvalho M.A., Correia C., Filipe Miguel Areias, Gutiérrez-de-Terán H., Loza M.I., Proença M.F., Rodriguez D.Fuentes:googlescopusSynthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics
ArticleAbstract: We describe the synthesis and binding affinities on D2, 5-HT2A and 5-HT2C receptors of 6-aminomethylPalabras claves:antipsychotics, Butyrophenones, dopamine, Isoxazole, Pyrazole, SerotoninAutores:Barceló M., Brea J., Domínguez E., Filipe Miguel Areias, Loza M.I., Masaguer C.F., Raviña E.Fuentes:googlescopusSynthesis of novel chromene scaffolds for adenosine receptors
ArticleAbstract: A one-pot procedure was developed for the synthesis of novel 3-[amino(methoxy)methylene]-2-oxo-3,4-dPalabras claves:Autores:Brea J., Castro M., Costa M., Filipe Miguel Areias, Loza M.I., Proença M.F.Fuentes:googlescopusSynthesis, 3D-QSAR, and structural modeling of benzolactam derivatives with binding affinity for the D<inf>2</inf>and D<inf>3</inf> receptors
ArticleAbstract: A series of 37 benzolactam derivatives were synthesized, and their respective affinities for the dopPalabras claves:3D-QSAR, antipsychotics, Benzolactams, D /D selectivity 2 3, Dopamine receptorsAutores:Brea J., Domínguez E., Filipe Miguel Areias, López L., Loza M.I., Masaguer C.F., Ortega R., Pastor M., Sanz F., Selent J.Fuentes:scopusSynthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D<inf>3</inf> receptor ligands
ArticleAbstract: A series of new benzolactam derivatives was synthesized and the derivatives were evaluated for theirPalabras claves:antipsychotics, Arylpiperazines, Benzolactams, Dopamine receptors, Structure-activity relationshipAutores:Brea J., Filipe Miguel Areias, López L., Loza M.I., Masaguer C.F., Ortega R., Pastor M., Raviña E., Sanz F., Selent J.Fuentes:googlescopusSynthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics
ArticleAbstract: The complex etiology of schizophrenia has prompted researchers to develop clozapine-related multitarPalabras claves:Autores:Aranda R., Brea J., Domínguez E., Filipe Miguel Areias, López L., Loza M.I., Masaguer C.F., Pastor M., Raviña E., Sanz F., Selent J., Villalba K.Fuentes:googlescopus