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G-protein-coupled receptors oligomerization: Emerging signaling units and new opportunities for drug design
ArticleAbstract: G-protein-coupled receptors (GPCRs) are a widespread family of transmembrane receptors with differenPalabras claves:Dimers, disease, drug design, G-protein-coupled receptors, ligand, OligomerizationAutores:Borroto-Escuela D.O., Fuxe K., Garriga P., Ramon E., Rivera D., Tena-Campos M., W. Romero-FernandezFuentes:scopusGPCR heteromers and their allosteric receptor-receptor interactions
ArticleAbstract: The concept of intramembrane receptor-receptor interactions and evidence for their existences were iPalabras claves:Adenosine receptor, allosteric modulation, Dopamine receptors, GPCR, moonlighting, Oligomers, Receptor G protein coupling, Receptor interface, Receptor mosaic, Receptor recognition, Receptor signaling, Receptor trafficking, Triplet homologiesAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Ferraro L., Filip M., Frankowska M., Fuxe K., Guidolin D., Marcellino D., Tanganelli S., Tarakanov A.O., W. Romero-Fernandez, Woods A.S.Fuentes:scopusFibroblast growth factor receptor 1 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity
ArticleAbstract: Background: The hippocampus and its 5-hydroxytryptamine transmission plays an important role in deprPalabras claves:allosteric modulation, Depression, Fibroblast growth factor receptor, Heteroreceptor, neuronal plasticity, serotonin receptorsAutores:Agnati L.F., Belluardo N., Borroto-Escuela D.O., Ciruela F., Di Liberto V., Fuxe K., Mudó G., Narváez M., Pérez-Alea M., Tarakanov A.O., W. Romero-FernandezFuentes:scopusDissecting the conserved NPxxY motif of the M <inf>3</inf> muscarinic acetylcholine receptor: Critical role of Asp-7.49 for receptor signaling and multiprotein complex formation
ArticleAbstract: Acetylcholine challenge produces M 3 muscarinic acetylcholine receptor activation and accessory/scafPalabras claves:Desensitization, G protein-coupled receptors, Monomeric small G proteins, Muscarinic acetylcholine receptors, NPxxY motif, Phospholipase C, Phospholipase DAutores:Borroto-Escuela D.O., Ciruela F., Correia P.A., Fuxe K., García-Negredo G., Garriga P., W. Romero-FernandezFuentes:scopusDiversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization
ReviewAbstract: Allosteric receptor-receptor interactions in GPCR heteromers appeared to introduce an intermolecularPalabras claves:allosteric modulation, Biased recognition, Biased signaling, G protein-coupled receptor, Heterodimerization, Receptor diversity, Receptor heterodimers, Receptor-receptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Díaz-Cabiale Z., Ferraro L., Filip M., Fuxe K., Garriga P., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusDopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers
ArticleAbstract: Biochemical, histochemical and coimmunoprecipitation experiments have indicated the existence of antPalabras claves:allosteric modulation, Dopamine D R receptor 2, G protein-coupled receptors, Heteromerization, Neurotensin 1 receptor, protein-protein interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Brito I., Corrales F., Ferraro L., Fuxe K., Narváez M., Ravani A., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusHallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
ArticleAbstract: Dopamine D2LR-serotonin 5-HT2AR heteromers were demonstrated in HEK293 cells after cotransfection ofPalabras claves:2,5-Dimethoxy-4-iodoamphetamine, allosteric modulation, Antipsychotic drugs, dopamine D2 receptor, G-protein-coupled receptors, Heterodimerization, Heteroreceptor complexes, Lysergic acid diethylamide, Receptor-receptor interactions, Serotonin 5-HT2A receptorAutores:Agnati L.F., Borroto-Escuela D.O., Fuxe K., Narváez M., Oflijan J., W. Romero-FernandezFuentes:scopusOverproduction of human M<inf>3</inf> muscarinic acetylcholine receptor: An approach toward structural studies
ArticleAbstract: Human M3 muscarinic acetylcholine receptor (M3R), present in both the central and the peripheral nerPalabras claves:Codon optimization, Epitope tags, G-protein-coupled receptors, Muscarinic receptor, Overexpression, Semliki forest virusAutores:Borroto-Escuela D.O., Garriga P., W. Romero-FernandezFuentes:scopusMapping the interface of a GPCR Dimer: A structural model of the A<inf>2A</inf> Adenosine and D<inf>2</inf> dopamine receptor heteromer
ArticleAbstract: The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell membrane and allPalabras claves:A adenosine receptor 2A, allosteric modulation, D dopamine receptor 2, Dimer interface, dimerization, G protein-coupled receptor, Heteroreceptor complexAutores:Borroto-Escuela D.O., Carlsson J., Fuxe K., Jaiteh M., Kapla J., Lazarova T., Ranganathan A., Rodriguez D., W. Romero-FernandezFuentes:scopusRole of dimerization in dopamine d4 receptor biogenesis
ArticleAbstract: Dopamine receptors are G protein-coupled receptors critically involved in locomotion, reward, and coPalabras claves:ADHD, Chaperone, dimerization, dopamine D2 receptor, Dopamine D4 receptor, Endoplasmic reticulum, G proteincoupled receptors, Polymorphic variantsAutores:Borroto-Escuela D.O., Duchou J., Fuxe K., Skieterska K., Van Craenenbroeck K., W. Romero-FernandezFuentes:scopus