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G protein-coupled receptor heterodimerization in the Brain
Book PartAbstract: G protein-coupled receptors (GPCRs) play critical roles in cellular processes and signaling and havePalabras claves:allosteric modulation, Depression, Fibroblast growth factor receptor, neuronal plasticity, Receptor heterocomplex, serotonin receptorsAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Fuxe K., Garriga P., Narváez M., Palkovits M., Tarakanov A.O., W. Romero-FernandezFuentes:scopusGPCR heteromers and their allosteric receptor-receptor interactions
ArticleAbstract: The concept of intramembrane receptor-receptor interactions and evidence for their existences were iPalabras claves:Adenosine receptor, allosteric modulation, Dopamine receptors, GPCR, moonlighting, Oligomers, Receptor G protein coupling, Receptor interface, Receptor mosaic, Receptor recognition, Receptor signaling, Receptor trafficking, Triplet homologiesAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Ferraro L., Filip M., Frankowska M., Fuxe K., Guidolin D., Marcellino D., Tanganelli S., Tarakanov A.O., W. Romero-Fernandez, Woods A.S.Fuentes:scopusFibroblast growth factor receptor 1 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity
ArticleAbstract: Background: The hippocampus and its 5-hydroxytryptamine transmission plays an important role in deprPalabras claves:allosteric modulation, Depression, Fibroblast growth factor receptor, Heteroreceptor, neuronal plasticity, serotonin receptorsAutores:Agnati L.F., Belluardo N., Borroto-Escuela D.O., Ciruela F., Di Liberto V., Fuxe K., Mudó G., Narváez M., Pérez-Alea M., Tarakanov A.O., W. Romero-FernandezFuentes:scopusDiversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization
ReviewAbstract: Allosteric receptor-receptor interactions in GPCR heteromers appeared to introduce an intermolecularPalabras claves:allosteric modulation, Biased recognition, Biased signaling, G protein-coupled receptor, Heterodimerization, Receptor diversity, Receptor heterodimers, Receptor-receptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Díaz-Cabiale Z., Ferraro L., Filip M., Fuxe K., Garriga P., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusDopamine D2 and 5-hydroxytryptamine 5-HT<inf>2A</inf> receptors assemble into functionally interacting heteromers
ArticleAbstract: In view of the co-distribution of dopamine D2LR and 5-hydroxytryptamine 5-HT2A receptors (D2LR and 5Palabras claves:allosteric modulation, Dopamine D R receptor 2, G protein-coupled receptors, Heteromerization, protein-protein interactions, Serotonin 5-HT receptor 2AAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Fuxe K., Marcellino D., Tarakanov A.O., W. Romero-FernandezFuentes:scopusDopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions
ArticleAbstract: Dopamine D2 and D4 receptors partially codistribute in the dorsal striatum and appear to play a fundPalabras claves:allosteric modulation, Dopamine D R receptor 2, Dopamine D R receptor 4, G protein-coupled receptors, Heteromerization, Protein-protein interactions.Autores:Agnati L.F., Borroto-Escuela D.O., Craenenbroeck K.V., Fuxe K., Guidolin D., Haegeman G., Rivera A., Tarakanov A.O., W. Romero-Fernandez, Woods A.S.Fuentes:scopusDopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers
ArticleAbstract: Biochemical, histochemical and coimmunoprecipitation experiments have indicated the existence of antPalabras claves:allosteric modulation, Dopamine D R receptor 2, G protein-coupled receptors, Heteromerization, Neurotensin 1 receptor, protein-protein interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Brito I., Corrales F., Ferraro L., Fuxe K., Narváez M., Ravani A., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusHallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
ArticleAbstract: Dopamine D2LR-serotonin 5-HT2AR heteromers were demonstrated in HEK293 cells after cotransfection ofPalabras claves:2,5-Dimethoxy-4-iodoamphetamine, allosteric modulation, Antipsychotic drugs, dopamine D2 receptor, G-protein-coupled receptors, Heterodimerization, Heteroreceptor complexes, Lysergic acid diethylamide, Receptor-receptor interactions, Serotonin 5-HT2A receptorAutores:Agnati L.F., Borroto-Escuela D.O., Fuxe K., Narváez M., Oflijan J., W. Romero-FernandezFuentes:scopusOn the existence of a possible A<inf>2A</inf>-D<inf>2</inf>-β- arrestin2 complex: A<inf>2A</inf> agonist modulation of D<inf>2</inf> agonist-induced β-arrestin2 recruitment
ArticleAbstract: Given that coactivation of adenosine A2A (A2AR) and dopamine D2 (D2R) receptors results in the coaggPalabras claves:allosteric modulation, G-protein-coupled receptors, Heteromerization, Internalization, receptor-protein interactionAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Fuxe K., Tarakanov A.O., W. Romero-FernandezFuentes:scopusMapping the interface of a GPCR Dimer: A structural model of the A<inf>2A</inf> Adenosine and D<inf>2</inf> dopamine receptor heteromer
ArticleAbstract: The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell membrane and allPalabras claves:A adenosine receptor 2A, allosteric modulation, D dopamine receptor 2, Dimer interface, dimerization, G protein-coupled receptor, Heteroreceptor complexAutores:Borroto-Escuela D.O., Carlsson J., Fuxe K., Jaiteh M., Kapla J., Lazarova T., Ranganathan A., Rodriguez D., W. Romero-FernandezFuentes:scopus