Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo

Article

Abstract: Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease. LRRK2 mod

Palabras claves:

Autophagy, Chaperone-mediated autophagy, Chloroquine, G2019S LRRK2, Glucocerebrosidase, LC3, MLi-2, Parkinson's Disease, pSer129 α-synuclein, TFEB

Autores:

Albanese F., Finetti L., Giovanni Bernacchia, Lamonaca G., Mercatelli D., Morari M., Pizzi S., Shimshek D.R.

Fuentes:

scopus