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HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer
ArticleAbstract: BACKGROUND. A common germline variant in HSD3B1(1245A>C) encodes for a hyperactive 3β-hydroxysteroidPalabras claves:Autores:Almassi N., Alyamani M., Berk M.P., Chien C., Emamekhoo H., Figg W.D., Garcia J., Grivas P.D., Hu B., Hwang T.H., Koshkin V.S., Mendiratta P., Park S., Peer C.J., Richard J. Auchus, Rini B., Sharifi N., Taylor J., Tyler A., Upadhyay S.K.Fuentes:scopusSteroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities
ArticleAbstract: Galeterone is a steroidal CYP17A1 inhibitor, androgen receptor (AR) antagonist, and AR degrader, undPalabras claves:3βHSD, abiraterone, Androgens, CYP17A1, galeterone, metabolism, Prostate cancer, steroidsAutores:Alyamani M., Berk M.P., Li J., Li Z., Richard J. Auchus, Sharifi N., Tang J., Upadhyay S.K.Fuentes:scopus