Mostrando 8 resultados de: 8
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Journal of Steroid Biochemistry and Molecular Biology(4)
Biochemistry(2)
Journal of Biological Chemistry(2)
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Bioquímica(6)
Farmacología y terapéutica(6)
Química orgánica(3)
Fisiología humana(1)
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scopus(8)
A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone
ArticleAbstract: Abiraterone acetate is a potent inhibitor of human cytochrome P450c17 (CYP17A1, 17α-hydroxylase/17,2Palabras claves:abiraterone, androgen, CYP17A1, Cytochrome p450, Enzymology, Prostate cancer, steroidogenesisAutores:Bratoeff E., Garrido M., Peng H.M., Richard J. Auchus, Upadhyay S.K., Yoshimoto F.K.Fuentes:scopusEpoxidation activities of human cytochromes P450c17 and P450c21
ArticleAbstract: Some cytochrome P450 enzymes epoxidize unsaturated substrates, but this activity has not been descriPalabras claves:Autores:Anderson S.M., Peng H.M., Richard J. Auchus, Yoshimoto F.K., Zhang H.Fuentes:scopusHuman cytochrome P450 21A2, the major steroid 21-hydroxylase: Structure of the enzyme•progesterone substrate complex and rate-limiting C-H bond cleavage
ArticleAbstract: Cytochrome P450 (P450) 21A2 is the major steroid 21-hydroxylase, and deficiency of this enzyme is inPalabras claves:Autores:Egli M., Guengerich F.P., Lei L., Pallan P.S., Richard J. Auchus, Wang C., Waterman M.R., Yoshimoto F.K.Fuentes:scopusMechanism of 17α,20-lyase and new hydroxylation reactions of human cytochrome P450 17A1 <sup>18</sup>O labeling and oxygen surrogate evidence for a role of a perferryl oxygen
ArticleAbstract: Cytochrome P450 (P450) reactions can involve C-C bond cleavage, and several of these are critical inPalabras claves:Autores:Gonzalez E., Guengerich F.P., Richard J. Auchus, Yoshimoto F.K.Fuentes:scopusMinor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates
ArticleAbstract: The steroid hydroxylases CYP17A1 (P450c17, 17-hydroxylase/17,20-lyase) and CYP21A2 (P450c21, 21-hydrPalabras claves:Autores:Matthew S., Peng H.M., Richard J. Auchus, Sharma K.K., Stidd D., Yoshimoto F.K., Yoshimoto J.A., Zhou Y.Fuentes:scopusRapid kinetic methods to dissect steroidogenic cytochrome P450 reaction mechanisms
ReviewAbstract: All cytochrome P450 enzyme reactions involve a catalytic cycle with several discreet physical or chePalabras claves:Cytochrome p450, Kinetic isotope effect, Pre-steady state kinetics, Rapid chemical quench, Single turnover experiment, Stopped-flow kineticsAutores:Richard J. Auchus, Yoshimoto F.K.Fuentes:scopusSynthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2
ArticleAbstract: The human steroidogenic cytochromes P450 CYP17A1 (P450c17, 17α-hydroxylase/17,20-lyase) and CYP21A2Palabras claves:Autores:Desilets M., Richard J. Auchus, Yoshimoto F.K.Fuentes:scopusThe diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1)
ReviewAbstract: The steroid hydroxylation and carbon–carbon bond cleavage activities of cytochrome P450 17A1 (CYP17APalabras claves:17,20-Lyase, 17-Hydroxylase, androgen, Cytochrome p450, Hypertension, Metabolic switching, steroidogenesisAutores:Richard J. Auchus, Yoshimoto F.K.Fuentes:scopus