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A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone
ArticleAbstract: Abiraterone acetate is a potent inhibitor of human cytochrome P450c17 (CYP17A1, 17α-hydroxylase/17,2Palabras claves:abiraterone, androgen, CYP17A1, Cytochrome p450, Enzymology, Prostate cancer, steroidogenesisAutores:Bratoeff E., Garrido M., Peng H.M., Richard J. Auchus, Upadhyay S.K., Yoshimoto F.K.Fuentes:scopusRapid kinetic methods to dissect steroidogenic cytochrome P450 reaction mechanisms
ReviewAbstract: All cytochrome P450 enzyme reactions involve a catalytic cycle with several discreet physical or chePalabras claves:Cytochrome p450, Kinetic isotope effect, Pre-steady state kinetics, Rapid chemical quench, Single turnover experiment, Stopped-flow kineticsAutores:Richard J. Auchus, Yoshimoto F.K.Fuentes:scopusThe diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1)
ReviewAbstract: The steroid hydroxylation and carbon–carbon bond cleavage activities of cytochrome P450 17A1 (CYP17APalabras claves:17,20-Lyase, 17-Hydroxylase, androgen, Cytochrome p450, Hypertension, Metabolic switching, steroidogenesisAutores:Richard J. Auchus, Yoshimoto F.K.Fuentes:scopus