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Human cytochrome P450 21A2, the major steroid 21-hydroxylase: Structure of the enzyme•progesterone substrate complex and rate-limiting C-H bond cleavage
ArticleAbstract: Cytochrome P450 (P450) 21A2 is the major steroid 21-hydroxylase, and deficiency of this enzyme is inPalabras claves:Autores:Egli M., Guengerich F.P., Lei L., Pallan P.S., Richard J. Auchus, Wang C., Waterman M.R., Yoshimoto F.K.Fuentes:scopusMechanism of 17α,20-lyase and new hydroxylation reactions of human cytochrome P450 17A1 <sup>18</sup>O labeling and oxygen surrogate evidence for a role of a perferryl oxygen
ArticleAbstract: Cytochrome P450 (P450) reactions can involve C-C bond cleavage, and several of these are critical inPalabras claves:Autores:Gonzalez E., Guengerich F.P., Richard J. Auchus, Yoshimoto F.K.Fuentes:scopus