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Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: In silico, in vitro and in vivo activity studies
ArticleAbstract: The synthesis and potent antiprotozoal activity of 14-hydroxylunularin, a natural hydroxybibenzyl brPalabras claves:bryophytes, Hydroxybibenzyl constituents, LEISHMANIA, TOMOCOMD software, TRYPANOSOMA CRUZIAutores:Ferreira M.E., Gómez-Barrio A., Heguaburu V., Montero-Torres A., Nakayama H., Pandolfi E., Rojas-De-Arias A., Roldos V., Rolón M.S., Sanabria L., Torres S., Trucco F., Vega C., Yaluff G., Yovani Marrero-PonceFuentes:googlescopusNon-stochastic quadratic fingerprints and LDA-based QSAR models in hit and lead generation through virtual screening: theoretical and experimental assessment of a promising method for the discovery of new antimalarial compounds
ArticleAbstract: In order to explore the ability of non-stochastic quadratic indices to encode chemical information iPalabras claves:Antimalarial compounds, Lda, Non-stochastic quadratic index, QSAR, ToMoCoMD-CARDD softwareAutores:Arán V.J., García-Sánchez R.N., Machado-Tugores Y., Martínez-Fernández A.R., Meneses-Marcel A., Montero-Torres A., Nogal-Ruiz J.J., Ochoa C., Torrens F., Yovani Marrero-PonceFuentes:googlescopusSynthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
ArticleAbstract: Chagas disease chemotherapy, currently based on only two drugs, nifurtimox and benznidazole, is farPalabras claves:Antiprotozoan agents, Chagas disease, CLÚSTER ANALYSIS, Cytotoxicity, Indazoles, Structure-activity relationshipsAutores:Arán V.J., Fonseca-Berzal C., Gálvez J., García-Trevijano J.A.E., Gómez-Barrio A., Montero-Torres A., Rolón M.S., Vega M.C., Yovani Marrero-PonceFuentes:googlescopus