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Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses
ArticleAbstract: COVID-19 is associated with neurological complications including stroke, delirium and encephalitis.Palabras claves:Autoantibodies, Brain injury, covid-19, neuroinflammationAutores:Allinson K., Allison J., Alvio G., Ansaripour A., Anwar F., Ashton N.J., Baker S., Barcenas-Morales G., Bergamaschi L., Bermperi A., Betancourt A., Bhatti J., Biggs H., Bong S.H., Bower G., Bradley J.R., Breen G., Brookes K., Bucke A., Bullman B., Bullmore E.T., Bunclark K., Burnstein R.M., Butcher H., Caddy S., Calder J., Caller L., Canna L., Caputo D., Cavanagh J., Chandler M., Chatfield D.A., Chaudhry Y., Chinnery P.F., Christmas D., Clapham-Riley D., Coles A.J., Coles J.P., Cooper D., Correia M., Cossetti C., Crucusio C., Das T., Digby R.J., Doffinger R., Dunai C., Dunning J., Ebrahimi S., Edé A., Elmer A., Emma Jones, Fletcher P.C., Fonseca C., Gisslé M., Griffiths M.J., Irani S.R., Jubb A.W., Kingston N., Leibowitz M.M., Lupson V.C., Lyons P.A., Manktelow A.E., Marklund E., Menon D.K., Michael B.D., Michell A., Needham E.J., Newcombe V.F.J., Norton E.J., Openshaw P.J.M., Outtrim J.G., Pointon L., Ren A.L., Rodgers C.T., Rowe J.B., Rua C., Samanta R.J., Sithole N., Smith K.G.C., Spindler L.R.B., Stamatakis E.A., Summers C., Taams L.S., Taussig M.J., Taylor J., Valerio F., Widmer B., Williams G.B., Zetterberg H.Fuentes:scopusA thermostable, closed SARS-CoV-2 spike protein trimer
ArticleAbstract: The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant tarPalabras claves:Autores:Baker S., Baxendale H.E., Bergamaschi L., Betancourt A., Bower G., Bradley J.R., Briggs J.A.G., Bucke A., Bullman B., Butcher H., Calder J., Canna L., Caputo D., Carter A.P., Ciazynska K.A., Crucusio C., de Sa A., Dewhust E., Doffinger R., Domingo J., Dunmore B.J., Ebrahimi S., Elmer A., Emma Jones, Epping M., Fawke S., Goodfellow I.G., Graf S., Graves B., Grice G.L., Harris J., Hewitt S., Hodgson J., Hosmillo M., Huang C., Huhn O., Hunter K., James L.C., Jarvis I., Jose S., Ke Z., Kennet J., Kourampa J., Le Gresley E., Legchenko E., Li E., Lyons P.A., Marsden J., Martin J., Meadows A., Mescia F., Nathan J.A., Nice F., Omarjee O., Ovington N., O’Brien C., O’Donnell C., Papadia S., Perera M., Pointon L., Pond N., Price J., Qu K., Rastall R., Ribeiro C., Richoz N., Rowlands J., Ruffolo V., Scheres S.H.W., Sharma R., Shih J., Smith K.G.C., Stark H., Stirrups K., Sutcliffe R., Tilly T., Tong Z., Tordesillas H., Toshner M., Treacy C., Turner L., Walker N., Wood J., Wylot M., Xiong X., Zhang Y.Fuentes:scopusLongitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease
ArticleAbstract: The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assesPalabras claves:bystander CD8+ T cell, complement, covid-19, immune pathology, INTERFERÓN, recovery, SARS-COV-2, Systemic inflammation, TNF-αAutores:Allison J., Ansaripour A., Baker S., Bergamaschi L., Betancourt A., Bong S.H., Bower G., Bradley J.R., Bucke A., Bullman B., Bunclark K., Butcher H., Calder J., Calero-Nieto F.J., Canna L., Caputo D., Clapham-Riley D., Cossetti C., Coudert J.D., de Bie E.M.D.D., de Sa A., Dewhurst E., di Stefano G., Doffinger R., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Fahey C., Fawke S., Fuller S., Furlong A., Gerber P.P., Gleadall N., Goodfellow I.G., Göttgens B., Graf S., Graves B., Gray J., Grenfell R., Gupta R.K., Hanson A.L., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Holmes E., Hosmillo M., Huang C., Huhn O., Hunter K., Ivers T., Jackson S., Jarvis I., Jose S., Josipovic M., Kasanicki M., Kennet J., Kingston N., Kotagiri P., Kourampa J., Laurenti E., Le Gresley E., Legchenko E., Lehner P.J., Lewis D., Linger R., Lyons P.A., Mackay M., Marioni J.C., Marsden J., Martin J., Matara C., Matheson N.J., Meadows A., Meloy S., Mende N., Mescia F., Michael A., Michel R., Morgan M.D., Muldoon F., Mwaura L., Nice F., Nicholson J.K., Petrunkina A.M., Richardson S., Ruffieux H., Saunders C., Smith K.G.C., Thaventhiran J.E.D., Toonen E.J.M., Toshner M., Turner L., Weekes M.P., Wills M.R.Fuentes:scopusSARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
ArticleAbstract: The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was fiPalabras claves:Autores:Abdullahi A., Abraham P., Agarwal M., Albecka A., Asakura H., Bashyam M.D., Bhat M., Biswas N.K., Brown J., Caputo D., Charles O.J., Chattopadhyay P., Chaudhary U., Chauhan H., Cherian S.S., Chiba M., Chinnaswamy S., Collier D.A., Dalal A., Das S., Datir R.P., Datta M., Datta S., Desai A.S., Devi P., Dhar M.S., Dikid T., Emma Jones, Ferreira I.A.T.M., Goel N., Gogia H., Goonawardane N., Ito J., Kabra S., Kawabata R., Kemp S.A., Kimura I., Kosugi Y., Kumar S., Kumari S., Lall H., Madan P., Maitra A., Mani R.S., Manjunatha M.V., Marwal R., Mayor S., Meena N., Mellan T., Meng B., Mishra S., Mlcochova P., Morizako N., Nagashima M., Nandicoori V., Oberoi J.K., Oide A., Palakodeti D., Pandey R., Papa G., Parida A., Pattabiraman C., Peacock T., Pillai A., Ponnusamy K., Potdar V.A., Prasad P., Radhakrishnan V.S., Raghav S.K., Ramakrishnan U., Raveendran R., Sadamasu K., Saito A., Sarin A., Satwik A., Scaria V., Sengupta S., Seshasayee A.S.N., Sharma R., Sharma U., Shouche Y.S., Singh M.K., Singh P., Singh S., Sivasubbu S., Soni N., Sowpati D.T., Suganami M., Tallapaka K.B., Thangaraj K., Udupi G.A., Uriu K., Vaishya R., Verma K., Wattal C., Whittaker C., Yokoyama M., Yoshimura K., Zhou J.Fuentes:scopusSARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity
ArticleAbstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike N-terminal domain (NTD) remaiPalabras claves:CP: Microbiology, DELTA, entry, fusogenicity, NTD, Omicron, Organoid, SARS-COV-2, spike, TMPRSS2Autores:Allison J., Baker S., Betancourt A., Bower G., Bucke A., Bullman B., Bunclark K., Butcher H., Calder J., Canna L., Caputo D., Choi J., Clapham-Riley D., Cossetti C., Datir R.P., de Bie E.M.D.D., de Sa A., Dewhurst E., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Fawke S., Fuller S., Furlong A., Gleadall N., Graf S., Graves B., Gray J., Grenfell R., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Huang C., Hunter K., Ivers T., Jackson S., Jarvis I., Jose S., Josipovic M., Kennet J., Kingston N., Kourampa J., Krishna B., Le Gresley E., Legchenko E., Lehner P.J., Linger R., Lyons P.A., Mackay M., Martin J., Matara C., Matheson N.J., Maxwell P., Meadows A., Meloy S., Meng B., Mescia F., Muldoon F., Nice F., O'Brien C., O'Donnell C., Omarjee O., Ovington N., Owehand W.H., Papadia S., Perera M., Phelan I., Pointon L., Potts M., Price J., Publico C., Rastall R., Ribeiro C., Richoz N., Romashova V., Rowlands J., Ruffolo V., Saunders C., Shaw A., Shih J., Stark H., Stefanucci L., Strezlecki M., Summers C., Sutcliffe R., Thaventhiran J.E.D., Tilly T., Tong Z., Tordesillas H., Toshner M., Treacy C., Turner L., Weekes M.P., Wood J., Wylot M.Fuentes:scopus