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A metabolic perspective of late onset Alzheimer's disease
ReviewAbstract: After decades of research, the molecular neuropathology of Alzheimer's disease (AD)is still one of tPalabras claves:Alzheimer's disease, c-Jun N-terminal kinase inhibitors, Insulin, Licochalcone A, neuroinflammation, Reticulum stress, Type 2 Diabetes mellitusAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Castro-Torres R.D., Ettcheto M., Folch J., García M.L., Manzine P.R., Olloquequi J., Sanchez-Lopez E., Verdaguer E., Zárate C.B.Fuentes:scopusCorrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer's disease” [J. Mech. Ageing Dev. 162 (March) (2017) 38-45](S0047637416300859)(10.1016/j.mad.2016.11.002)
OtherAbstract: The authors regret that there are some errors in the original Figures 2, 3 and 5. A reader brought tPalabras claves:Autores:Antoni Camins, Auladell C., Busquets O., Ettcheto M., Folch J., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusEarly Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer’s Disease
ArticleAbstract: The molecular basis of memory loss in Alzheimer’s disease (AD), the main cause of senile dementia, iPalabras claves:Alzheimer disease, APPswe/PS1dE9, CBP, CREB, hippocampusAutores:Abad S., Antoni Camins, Auladell C., Busquets O., Carro E., Casadesús G., Ettcheto M., Folch J., Olloquequi J., Pallás M., Pedros I., Petrov D., Sanchez-Lopez E., Zárate C.B.Fuentes:scopusPeripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer’s Disease
ArticleAbstract: There is growing evidence that obesity associated with type 2 diabetes mellitus (T2DM) and aging arePalabras claves:Alzheimer’s disease, APPswe/PS1dE9, DIABÉTES, high-fat diet, Memantine, obesityAutores:Antoni Camins, Auladell C., Busquets O., Cabrera H., Carro E., Casadesús G., Ettcheto M., Folch J., García M.L., Gómez-Mínguez Y., Sanchez-Lopez E., Vázquez-Carrera M., Zárate C.B.Fuentes:scopusInvolvement of JNK1 in Neuronal Polarization During Brain Development
ReviewAbstract: The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control oPalabras claves:asymmetric division, DCX, JNK1, MAP1B, MIGRATION, NMDAR, SCG10, synaptogenesis, WDR62Autores:Antoni Camins, Auladell C., Busquets O., Castro-Torres R.D., Ettcheto M., Folch J., Olloquequi J., Parcerisas A., Verdaguer E., Zárate C.B.Fuentes:scopusJNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy
ArticleAbstract: Neurogenesis in the adult dentate gyrus (DG) of the hippocampus allows the continuous generation ofPalabras claves:adult hippocampal neurogenesis, JNK isoforms, Kainic acid, Knockout miceAutores:Antoni Camins, Auladell C., Busquets O., Castro-Torres R.D., Ettcheto M., Folch J., Landa J., Olloquequi J., Rabaza M., Verdaguer E., Zárate C.B.Fuentes:scopusJNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function
ArticleAbstract: Background and aim: The appearance of alterations in normal metabolic activity has been increasinglyPalabras claves:COGNITION, high-fat diet, JNK1, JNK3, metabolismAutores:Antoni Camins, Auladell C., Bulló M., Busquets O., Cantero J.L., Carro E., Casadesús G., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Verdaguer E.Fuentes:scopusJNK1 inhibition by Licochalcone A leads to neuronal protection against excitotoxic insults derived of kainic acid
ArticleAbstract: The mitogen-activated protein kinase family (MAPK) is an important group of enzymes involved in cellPalabras claves:Epilepsy, hippocampus, Kainic acid, Licochalcone A, NeurodegenerationAutores:Antoni Camins, Auladell C., Busquets O., Castro-Torres R.D., Ettcheto M., Folch J., Verdaguer E., Zárate C.B.Fuentes:scopusc-Jun N-terminal Kinase 1 ablation protects against metabolic-induced hippocampal cognitive impairments
ArticleAbstract: Abstract: The development of metabolic alterations like insulin resistance has been associated withPalabras claves:c-Jun N-terminal Kinase 1, Cognitive impairments, high-fat dietAutores:Antoni Camins, Auladell C., Bulló M., Busquets O., Casadesús G., Castro-Torres R.D., Eritja À., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusRole of brain c-Jun N-terminal kinase 2 in the control of the insulin receptor and its relationship with cognitive performance in a high-fat diet pre-clinical model
ArticleAbstract: Insulin resistance has negative consequences on the physiological functioning of the nervous system.Palabras claves:ER stress, high-fat diet, JNK, metabolism, neuroinflammation, PTP1BAutores:Antoni Camins, Auladell C., Busquets O., Castro-Torres R.D., Eritja À., Ettcheto M., Folch J., López B.M., Manzine P.R., Olloquequi J., Vázquez-Carrera M., Verdaguer E.Fuentes:scopus