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Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer’s Disease
ArticleAbstract: There is growing evidence that obesity associated with type 2 diabetes mellitus (T2DM) and aging arePalabras claves:Alzheimer’s disease, APPswe/PS1dE9, DIABÉTES, high-fat diet, Memantine, obesityAutores:Antoni Camins, Auladell C., Busquets O., Cabrera H., Carro E., Casadesús G., Ettcheto M., Folch J., García M.L., Gómez-Mínguez Y., Sanchez-Lopez E., Vázquez-Carrera M., Zárate C.B.Fuentes:scopusPeroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations
ArticleAbstract: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the centPalabras claves:dendritic spines, high-fat diet, insulin signaling, Memory impairment, neuroinflammation, PPARβ/δ, synapsis, T2DMAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Parcerisas A., Sanchez-Lopez E., Vázquez-Carrera M., Verdaguer E., Wahli W.Fuentes:scopusLong-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer's disease
ArticleAbstract: Aims The sporadic and late-onset form of Alzheimer's disease (AD) constitutes the most common form oPalabras claves:AD, Alzheimer's disease, AMP-activated protein kinase, AMPK, ANS, autonomic nervous system, Aβ, BACE1, BBB, beta-site APP-cleaving enzyme 1, brain blood barrier, Cerebrospinal fluid, CSF, diet-induced obesity, DIO, HCD, HFD, high calorie diet, high-fat diet, IGF-1, Insulin-like growth factor-1, late-onset Alzheimer's disease, LOAD, MAPK, mitogen-activated protein kinase, protein tyrosine phosphatase 1β, PTP1β, T2DM, Type 2 Diabetes mellitus, β-AmyloidAutores:Antoni Camins, Auladell C., Busquets O., Ettcheto M., Folch J., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusJNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function
ArticleAbstract: Background and aim: The appearance of alterations in normal metabolic activity has been increasinglyPalabras claves:COGNITION, high-fat diet, JNK1, JNK3, metabolismAutores:Antoni Camins, Auladell C., Bulló M., Busquets O., Cantero J.L., Carro E., Casadesús G., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Verdaguer E.Fuentes:scopusc-Jun N-terminal Kinase 1 ablation protects against metabolic-induced hippocampal cognitive impairments
ArticleAbstract: Abstract: The development of metabolic alterations like insulin resistance has been associated withPalabras claves:c-Jun N-terminal Kinase 1, Cognitive impairments, high-fat dietAutores:Antoni Camins, Auladell C., Bulló M., Busquets O., Casadesús G., Castro-Torres R.D., Eritja À., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusRole of brain c-Jun N-terminal kinase 2 in the control of the insulin receptor and its relationship with cognitive performance in a high-fat diet pre-clinical model
ArticleAbstract: Insulin resistance has negative consequences on the physiological functioning of the nervous system.Palabras claves:ER stress, high-fat diet, JNK, metabolism, neuroinflammation, PTP1BAutores:Antoni Camins, Auladell C., Busquets O., Castro-Torres R.D., Eritja À., Ettcheto M., Folch J., López B.M., Manzine P.R., Olloquequi J., Vázquez-Carrera M., Verdaguer E.Fuentes:scopus