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Article(6)
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Clinical Cancer Research(1)
Journal of Molecular Modeling(1)
Journal of Structural Biology(1)
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Protein Engineering, Design and Selection(1)
Canonical or noncanonical? Structural plasticity of serine protease-binding loops in Kunitz-STI protease inhibitors
ArticleAbstract: The Kunitz-Soybean Trypsin Inhibitor (Kunitz-STI) family is a large family of proteins with most ofPalabras claves:canonical inhibitors, Kunitz, noncanonical inhibitors, protease inhibitors, serine proteaseAutores:Berry C., Eduardo Tejera, Pons T., Vinicio Danilo Armijos-Jaramillo, Yasel GuerraFuentes:googlescopusExome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of antiangiogenic therapies
ArticleAbstract: Purpose: Despite the wide use of antiangiogenic drugs in the clinical setting, pbkp_redictive biomarPalabras claves:Autores:Albarran M.I., Alvarez R., Banos N., Blanco-Aparicio C., Camacho-Artacho M., Cubillo A., De Martino A., Domínguez O., Durán Y., Garralda E., Hidalgo M., Lietha D., Martínez-Torrecuadrada J.L., Mitsi M., Monsech J., Otero A., Perea S., Pons T., Sanchez-Perez T., Sarno F., Toledo R.A., Vega E., Victoria Maritza Cevallos BonillaFuentes:scopusTwo aspartate residues at the putative p10 subunit of a type II metacaspase from Nicotiana tabacum L. may contribute to the substrate-binding pocket
ArticleAbstract: Metacaspases are cysteine proteases present in plants, fungi, prokaryotes, and early branching eukarPalabras claves:Autoprocessing, Cell death, protein modeling, Transient expressionAutores:Acosta-Maspons A., Lien González-Pérez, Marrero-Gutiérrez J., Pons T., Rocha-Sosa M., Sánchez-Baldoquín L., Sepúlveda-García E.Fuentes:scopusValidation of a mutant of the pore-forming toxin sticholysin-I for the construction of proteinase-activated immunotoxins
ArticleAbstract: The use of pore-forming toxins from sea anemones (actinoporins) in the construction of immunotoxinsPalabras claves:Actinoporin, immunotoxin, Pore-forming toxin, sea anemone cytolysin, sticholysinsAutores:Álvarez C., Calvo L., Campos J., Castellanos‐Serra L., Cilli E.M., Díaz I., Fando R., Lanio M.E., Pazos I., Pentón D., Pérez-Barzaga V., Pons T., Reytor M.L., Tejuca M., Vivian Morera CórdovaFuentes:scopusPbkp_redicting functional residues of the Solanum lycopersicum aspartic protease inhibitor (SLAPI) by combining sequence and structural analysis with molecular docking
ArticleAbstract: The Solanum lycopersicum aspartic protease inhibitor (SLAPI), which belongs to the STI-Kunitz familyPalabras claves:Aspartic protease inhibitor, Comparative 3D modeling, Functional residue identification, Protein-protein docking, Protein-protein interface, STI-Kunitz inhibitorAutores:Berry C., Pons T., Valiente P.A., Yasel GuerraFuentes:googlescopusStructures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: Could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop?
ArticleAbstract: Bi-functional inhibitors from the Kunitz-type soybean trypsin inhibitor (STI) family are glycosylatePalabras claves:Aspartic protease inhibitors, Bi-functional inhibitors, Kunitz-type STI family inhibitors, Plant protease inhibitors, β-Trefoil foldAutores:Berry C., Pons T., Rudino-Pinera E., Valiente P.A., Yasel GuerraFuentes:googlescopus